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dc.contributor.author
Netti, Vanina Alejandra
dc.contributor.author
Iovane, Agustina N.
dc.contributor.author
Vatrella, Mariana C.
dc.contributor.author
Zotta, Elsa
dc.contributor.author
Fellet, Andrea L.
dc.contributor.author
Balaszczuk, Ana Maria
dc.date.available
2018-03-28T18:45:00Z
dc.date.issued
2016-07
dc.identifier.citation
Netti, Vanina Alejandra; Iovane, Agustina N.; Vatrella, Mariana C.; Zotta, Elsa; Fellet, Andrea L.; et al.; Effects of nitric oxide system and osmotic stress on Aquaporin-1 in the postnatal heart; Elsevier Masson; Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie; 81; 7-2016; 225-234
dc.identifier.issn
0753-3322
dc.identifier.uri
http://hdl.handle.net/11336/40446
dc.description.abstract
Aquaporin-1 (AQP1) is expressed in the heart and its relationship with NO system has not been fully explored. The aims of this work were to study the effects of NO system inhibition on AQP1 abundance and localization and evaluate AQP1 S-nitrosylation in a model of water restriction during postnatal growth. Rats aged 25 and 50 days (n = 15) were divided in: R: water restriction; C: water ad libitum; RL: L-NAME (4 mg/kg day) + water restriction; CL: L-NAME + water ad libitum. AQP1 protein levels, immunohistochemistry and S-nitrosylation (colocalization of AQP1 and S-nitrosylated cysteines by confocal microscopy) were determined in cardiac tissue. We also evaluated the effects of NO donor sodium nitroprusside (SNP) on osmotic water permeability of cardiac membrane vesicles by stopped-flow spectrometry. AQP1 was present in cardiac vascular endothelium and endocardium in C and CL animals of both ages. Cardiac AQP1 levels were increased in R50 and RL50 and appeared in cardiomyocyte plasma membrane. No changes in AQP1 abundance or localization were observed in R25, but RL25 group showed AQP1 presence on cardiomyocyte sarcolemma. AQP1 S-nitrosylation was increased in R25 group, without changes in the 50-day-old group. Cardiac membrane vesicles expressing AQP1 presented a high water permeability coefficient and pretreatment with SNP decreased water transport. Age-related influence of NO system on AQP1 abundance and localization in the heart may affect cardiac water homeostasis during hypovolemic state. Increased AQP1 S-nitrosylation in the youngest group may decrease osmotic water permeability of cardiac membranes, having a negative impact on cardiac water balance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Masson
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Aquaporin-1
dc.subject
Dehydration
dc.subject
Heart
dc.subject
Nitric Oxide
dc.subject
Postnatal Growth
dc.subject.classification
Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effects of nitric oxide system and osmotic stress on Aquaporin-1 in the postnatal heart
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-28T16:58:46Z
dc.journal.volume
81
dc.journal.pagination
225-234
dc.journal.pais
Francia
dc.journal.ciudad
Paris
dc.description.fil
Fil: Netti, Vanina Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Iovane, Agustina N.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina
dc.description.fil
Fil: Vatrella, Mariana C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina
dc.description.fil
Fil: Zotta, Elsa. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiopatogenia; Argentina
dc.description.fil
Fil: Fellet, Andrea L.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Balaszczuk, Ana Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina
dc.journal.title
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.biopha.2016.03.050
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0753332216301469
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