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dc.contributor.author
Gallegos, Cristina Eugenia  
dc.contributor.author
Michelin, Severino  
dc.contributor.author
Dubner Diana  
dc.contributor.author
Carosella, Edgardo D.  
dc.date.available
2018-03-28T17:19:29Z  
dc.date.issued
2016-05  
dc.identifier.citation
Gallegos, Cristina Eugenia; Michelin, Severino; Dubner Diana; Carosella, Edgardo D.; Immunomodulation of classical and non-classical HLA molecules by ionizing radiation; Academic Press Inc Elsevier Science; Cellular Immunology; 303; 5-2016; 16-23  
dc.identifier.issn
0008-8749  
dc.identifier.uri
http://hdl.handle.net/11336/40409  
dc.description.abstract
Radiotherapy has been employed for the treatment of oncological patients for nearly a century, and together with surgery and chemotherapy, radiation oncology constitutes one of the three pillars of cancer therapy. Ionizing radiation has complex effects on neoplastic cells and on tumor microenvironment: beyond its action as a direct cytotoxic agent, tumor irradiation triggers a series of alterations in tumoral cells, which includes the de novo synthesis of particular proteins and the up/down-regulation of cell surface molecules. Additionally, ionizing radiation may induce the release of "danger signals" which may, in turn lead to cellular and molecular responses by the immune system. This immunomodulatory action of ionizing radiation highlights the importance of the combined use (radiotherapy plus immunotherapy) for cancer healing. Major histocompatibility complex antigens (also called Human Leukocyte Antigens, HLA in humans) are one of those molecules whose expression is modulated after irradiation. This review summarizes the modulatory properties of ionizing radiation on the expression of HLA class I (classical and non-classical) and class II molecules, with special emphasis in non-classical HLA-I molecules.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Academic Press Inc Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Human Leukocyte Antigens  
dc.subject
Ionizing Radiation  
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Radiotherapy  
dc.subject.classification
Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Immunomodulation of classical and non-classical HLA molecules by ionizing radiation  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-28T16:56:15Z  
dc.journal.volume
303  
dc.journal.pagination
16-23  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina. Autoridad Regulatoria Nuclear; Argentina  
dc.description.fil
Fil: Michelin, Severino. Autoridad Regulatoria Nuclear; Argentina  
dc.description.fil
Fil: Dubner Diana. Autoridad Regulatoria Nuclear; Argentina  
dc.description.fil
Fil: Carosella, Edgardo D.. Institute of Emerging Diseases and Innovative Therapies; Francia. University Paris Diderot; Francia  
dc.journal.title
Cellular Immunology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cellimm.2016.04.005  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0008874916300211