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dc.contributor.author
Muzzio, Damián  
dc.contributor.author
Foglia, María Lucía  
dc.contributor.author
Desimone, Martín Federico  
dc.contributor.author
Zygmunt, Marek  
dc.date.available
2018-03-28T16:37:49Z  
dc.date.issued
2017-07  
dc.identifier.citation
Muzzio, Damián; Foglia, María Lucía; Desimone, Martín Federico; Zygmunt, Marek; 3D in vitro models of early pregnancy: How to choose the right scaffolding material?; Bentham Science Publishers; Current Pharmaceutical Design; 23; 24; 7-2017; 3603-3613  
dc.identifier.issn
1381-6128  
dc.identifier.uri
http://hdl.handle.net/11336/40368  
dc.description.abstract
Following fertilization, the blastocyst has to complete two distinct steps to assure further development of pregnancy. After apposition it establishes a firm connection with the luminal epithelium of the endometrium (attachment) and subsequently enters the decidualizing stroma (invasion). If this step is not achieved successfully, fertility problems arise. Development of the placenta ensures an adequate supply of nutrients and gas between the mother and the fetus. Preeclampsia is a prevalent disorder arising from defects in the process of placentation. It is associated with an increase of maternal morbidity and mortality. Numerous attempts have been made in order to elucidate the etiology of the syndrome and identify women at risk. The lack of reliable animal models has turned the attention to the development of in vitro assays, which could provide a better insight into the individual processes that will later trigger preeclampsia symptoms. In particular, 3D in vitro models more closely resemble the complexity of the extracellular environment. The choice of the scaffolding material should be done carefully as cell-matrix interactions are very often as important as cell-cell interactions for the correct attachment, proliferation and differentiation of cells. The following review is aimed to provide a general overview of the scaffolds available for the in vitro modeling of these complicated systems as well as to discuss the importance surrounding the choice of the scaffolding material and its influence on the results obtained.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Bentham Science Publishers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
3d in Vitro Models  
dc.subject
Biomaterials  
dc.subject
Decidualizing Stroma  
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Early Pregnancy  
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Endometrium  
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Scaffolds  
dc.subject.classification
Otras Biotecnologías de la Salud  
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Biotecnología de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
3D in vitro models of early pregnancy: How to choose the right scaffolding material?  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-28T14:10:39Z  
dc.journal.volume
23  
dc.journal.number
24  
dc.journal.pagination
3603-3613  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Oak Park  
dc.description.fil
Fil: Muzzio, Damián. Universitätsmedizin Greifswald; Alemania  
dc.description.fil
Fil: Foglia, María Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina  
dc.description.fil
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina  
dc.description.fil
Fil: Zygmunt, Marek. Universitätsmedizin Greifswald; Alemania  
dc.journal.title
Current Pharmaceutical Design  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/152275/article  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1381612823666170509104848