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dc.contributor.author
Besuhli, Valeria
dc.contributor.author
Lomniczi, A.
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Elverdín, Juan Carlos
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Suburo, Angela Maria
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Faletti, Alicia Graciela
dc.contributor.author
Franchi, Ana Maria
dc.contributor.author
McCann, Samuel M.
dc.date.available
2018-03-28T14:51:19Z
dc.date.issued
2006-01
dc.identifier.citation
Besuhli, Valeria; Lomniczi, A.; Elverdín, Juan Carlos; Suburo, Angela Maria; Faletti, Alicia Graciela; et al.; Control of Salivary Secretion by Nitric Oxide and Its Role in Neuroimmunomodulation; Blackwell Publishing; Annals of the New York Academy of Sciences; 917; 1; 1-2006; 258-267
dc.identifier.issn
0077-8923
dc.identifier.uri
http://hdl.handle.net/11336/40355
dc.description.abstract
Abstract: In many in vivo systems exposure to endotoxins (LPS) leads to the co‐induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2), which is important to the regulation of the function of different systems during infection. In submandibular glands (SMG) neural (n)NOS is localized in neural terminals and in striated, granular convoluted and excretory ducts, endothelial (e) NOS in vascular endothelium and ducts, and iNOS in macrophages and in tubules and ducts. In normal adult male rats, injection of an inhibitor of NOS decreased the stimulated salivary secretion and a donor of NO potentiated it, indicating that NO exerts a stimulatory role. A single high dose of LPS (5 mg/kg, i.p.) induced an increase in NOS activity measured by the 14C‐citrulline method, increased PGE content almost 100% as measured by RIA, and blocked stimulated salivary secretion. The administration of a specific iNOS inhibitor, aminoguanidine (AG), with LPS not only decreased NOS activity but significantly decreased PGE content, indicating that NO triggered the activation of COX‐2. LPS increased conversion of labeled arachidonate to prostaglandins (PGs) showing that COX was induced. Since a PGE1 analogue blocked stimulated salivation, the LPS‐induced inhibition of salivation is probably due to release of PGs. Therefore, the use of inhibitors of iNOS and COX‐2 could be very useful to increase salivation during infection since saliva has antimicrobial actions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Blackwell Publishing
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Otras Medicina Básica
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Control of Salivary Secretion by Nitric Oxide and Its Role in Neuroimmunomodulation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-16T15:15:10Z
dc.journal.volume
917
dc.journal.number
1
dc.journal.pagination
258-267
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Besuhli, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Lomniczi, A.. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Elverdín, Juan Carlos. Universidad de Buenos Aires. Facultad de Odontología; Argentina
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Fil: Suburo, Angela Maria. Universidad Austral; Argentina
dc.description.fil
Fil: Faletti, Alicia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Franchi, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: McCann, Samuel M.. State University of Louisiana; Estados Unidos
dc.journal.title
Annals of the New York Academy of Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1749-6632.2000.tb05391.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2000.tb05391.x
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