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dc.contributor.author
Ezquer, Fernando
dc.contributor.author
Giraud Billoud, Maximiliano German
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Carpio, Daniel
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Cabezas, Fabián
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Conget, Paulette
dc.contributor.author
Ezquer, Marcelo
dc.date.available
2018-03-27T21:33:10Z
dc.date.issued
2015-06
dc.identifier.citation
Ezquer, Fernando; Giraud Billoud, Maximiliano German; Carpio, Daniel; Cabezas, Fabián; Conget, Paulette; et al.; Proregenerative microenvironment triggered by donor mesenchymal stem cells preserves renal function and structure in mice with severe diabetes mellitus; Hindawi Publishing Corporation; BioMed Research International; 2015; 6-2015; 1-23
dc.identifier.issn
2314-6141
dc.identifier.uri
http://hdl.handle.net/11336/40293
dc.description.abstract
The aim of our work was to evaluate, in an animal model of severe diabetes mellitus, the effect of mesenchymal stem cells (MSCs) administration on diabetic nephropathy (DN) progression. After diabetes induction, one group of mice received the vehicle (DM) and other group received a single dose of MSCs (DM + MSCs). DM + MSCs mice showed a significant improvement in functional parameters of the kidney compared with untreated mice. While DM mice presented marked histopathological changes characteristics of advanced stages of DN (fibrosis, glomerulosclerosis, glomerular basement membrane thickening, capillary occlusion, decreased podocyte density, and effacement of foot processes), DM + MSCs mice showed only slight tubular dilatation. The renoprotection was not associated with an improvement in diabetic condition and very low number of donor cells was found in the kidney of DM + MSCs mice, suggesting that renoprotection could be mediated by paracrine effects. Indeed, DM + MSC mice presented increased renal proliferation index, decreased renal apoptotic index and the restoration of proregenerative factors, and anti-inflammatory cytokines levels. Moreover, macrophage infiltration and oxidative stress damage were also reduced in DM + MSCs mice. Our data demonstrate that MSC administration triggers a proregenerative microenvironment in DN kidney, which allows the preservation of the renal function even if diabetes was uncorrected.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Diabetes Mellitus
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Diabetic Nephropathy
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Mesenchymal Stem Cells
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Renal Function Recovery
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Pro-Regenerative Microenvironment
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Podocytes
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Glomerulosclerosis
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Proregenerative microenvironment triggered by donor mesenchymal stem cells preserves renal function and structure in mice with severe diabetes mellitus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-27T13:34:11Z
dc.journal.volume
2015
dc.journal.pagination
1-23
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Ezquer, Fernando. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
dc.description.fil
Fil: Giraud Billoud, Maximiliano German. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Carpio, Daniel. Universidad Austral de Chile; Chile
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Fil: Cabezas, Fabián. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile. Universidad Andrés Bello; Chile
dc.description.fil
Fil: Conget, Paulette. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
dc.description.fil
Fil: Ezquer, Marcelo. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
dc.journal.title
BioMed Research International
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2015/164703
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2015/164703/
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