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dc.contributor.author
Vieira Machado, Camilla D.  
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de Carvalho, Flavia M.  
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Santana da Silva, Luiz C.  
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dos Santos, Sidney E.  
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Martins, Claudia  
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Poletta, Fernando Adrián  
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Mereb, Juan C.  
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Vieira, Alexandre R.  
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Castilla, Eduardo Enrique  
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Orioli, Iêda M.  
dc.date.available
2018-03-27T17:44:35Z  
dc.date.issued
2016-08  
dc.identifier.citation
Vieira Machado, Camilla D.; de Carvalho, Flavia M.; Santana da Silva, Luiz C.; dos Santos, Sidney E.; Martins, Claudia; et al.; Analysis of the genetic ancestry of patients with oral clefts from South American admixed populations; Wiley Blackwell Publishing, Inc; European Journal Of Oral Sciences; 124; 4; 8-2016; 406-411  
dc.identifier.issn
0909-8836  
dc.identifier.uri
http://hdl.handle.net/11336/40171  
dc.description.abstract
Increased susceptibility to cleft lip, with or without cleft palate (CL±P) has been observed in South America, as related to Amerindian ancestry, using epidemiological data, uniparental markers, and blood groups. In this study, it was evaluated whether this increased risk remains when Amerindian ancestry is estimated using autosomal markers and considered in the predictive model. Ancestry was estimated through genotyping 62 insertion and deletion (INDEL) markers in sample sets of patients with CL±P, patients with cleft palate (CP), and controls, from Patagonia in southern Argentina and Belém in northern Brazil. The Amerindian ancestry in patients from Patagonia with CL±P was greater than in controls although it did not reach statistical significance. The European ancestry in patients with CL±P from Belém and in patients with CP from Belém and Patagonia was higher than in controls and statistically significant for patients with CP who were from Belém. This high contribution of European genetic ancestry among patients with CP who were from Belém has not been previously observed in American populations. Our results do not corroborate the currently accepted risks for CL±P and CP estimated by epidemiological studies in the North American populations and probably reflect the higher admixture found in South American ethnic groups when compared with the same ethnic groups from the North American populations.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Cleft Lip And Palate  
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Cleft Palate  
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Genetic Ancestry  
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Indel  
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South American Populations  
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Medicina Critica y de Emergencia  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Analysis of the genetic ancestry of patients with oral clefts from South American admixed populations  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-27T14:49:09Z  
dc.journal.volume
124  
dc.journal.number
4  
dc.journal.pagination
406-411  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Vieira Machado, Camilla D.. Universidade Federal do Rio de Janeiro; Brasil  
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Fil: de Carvalho, Flavia M.. Instituto Oswaldo Cruz; Brasil  
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Fil: Santana da Silva, Luiz C.. Universidade Federal do Rio de Janeiro; Brasil  
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Fil: dos Santos, Sidney E.. Universidade Federal do Pará; Brasil  
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Fil: Martins, Claudia. Ophir Loyola Hospital; Brasil  
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Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina  
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Fil: Mereb, Juan C.. Provincia de Río Negro. Ministerio de Salud. Hospital Zonal El Bolsón; Argentina  
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Fil: Vieira, Alexandre R.. University of Pittsburgh; Estados Unidos  
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Fil: Castilla, Eduardo Enrique. Instituto Oswaldo Cruz; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina  
dc.description.fil
Fil: Orioli, Iêda M.. Universidade Federal do Rio de Janeiro; Brasil  
dc.journal.title
European Journal Of Oral Sciences  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/eos.12275  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/eos.12275