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Artículo

Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury

Malet, MarianaIcon ; Leiguarda, CandelariaIcon ; Gastón, Guillermo Ariel; Mccarthy, Carly Jane; Brumovsky, Pablo RodolfoIcon
Fecha de publicación: 06/2017
Editorial: Elsevier Science Inc
Revista: Peptides
ISSN: 0196-9781
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Neuropeptide tyrosine (NPY) and its associated receptors Y1R and Y2R have been previously implicated in the spinal modulation of neuropathic pain induced by total or partial sectioning of the sciatic nerve. However, their role in chronic constrictive injuries of the sciatic nerve has not yet been described. In the present study, we analyzed the consequences of pharmacological activation of spinal Y1R, by using the specific Y1R agonist Leu31Pro34-NPY, in rats with chronic constriction injury (CCI). CCI and sham-injury rats were implanted with a permanent intrathecal catheter (at day 7 after injury), and their response to the administration of different doses (2.5, 5, 7, 10 or 20 μg) of Leu31Pro34-NPY (at a volume of 10 μl) through the implanted catheter, recorded 14 days after injury. Mechanical allodynia was tested by means of the up-and-down method, using von Frey filaments. Cold allodynia was tested by application of an acetone drop to the affected hindpaw. Intrathecal Leu31Pro34-NPY induced an increase of mechanical thresholds in rats with CCI, starting at doses of 5 μg and becoming stronger with higher doses. Intrathecal Leu31Pro34 also resulted in reductions in the frequency of withdrawal to cold stimuli, although the effect was somewhat more moderate and mostly observed for doses of 7 μg and higher. We thus show that spinal activation of the Y1R is able to reduce neuropathic pain due to a chronic constrictive injury and, together with other studies, support the use of a spinal Y1R agonist as a therapeutic agent against chronic pain induced by peripheral neuropathy.
Palabras clave: Allodynia , Inhibition , Neuropathic Pain , Neuropeptides , Sciatic Nerve , Spinal Cord
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/40162
DOI: http://dx.doi.org/10.1016/j.peptides.2017.04.005
URL: https://www.sciencedirect.com/science/article/pii/S0196978117301754
Colecciones
Articulos(IIMT)
Articulos de INSTITUTO DE INVESTIGACIONES EN MEDICINA TRASLACIONAL
Citación
Malet, Mariana; Leiguarda, Candelaria; Gastón, Guillermo Ariel; Mccarthy, Carly Jane; Brumovsky, Pablo Rodolfo; Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury; Elsevier Science Inc; Peptides; 92; 6-2017; 38-45
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