Mild thio-diversification of bioactive natural products. Withaferin A: A case study

A sustainable strategy was developed to create chemical diversity from bioactive scaffolds. The methodology comprises a set of simple reactions between the parent compound (i. e. withaferin A), and small sulfur nucleophiles in hydroalcoholic media, at room temperature and in open-air atmosphere. Novel steroidal sulfur natural product-analogs were obtained, featuring ring opening, ring formation, new stereocenters and modulation of parameters useful in medicinal chemistry.

Palabras clave: Natural Products , Sulfur Heterocycles , Sulfur Nucleophiles , Sustainable Chemistry , Withaferin A

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/40086

URL: https://onlinelibrary.wiley.com/doi/full/10.1002/slct.201701870

DOI: http://dx.doi.org/10.1002/slct.201701870

Colecciones

Articulos(CIQUIBIC)
Articulos de CENTRO DE INVEST.EN QCA.BIOL.DE CORDOBA (P)

Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)

Citación

Casero, Carina Noelia; Garay Novillo, Javier Nicolás; García, Manuela Emila; Oberti, Juan Carlos María; Nicotra, Viviana Estela; et al.; Mild thio-diversification of bioactive natural products. Withaferin A: A case study; Wiley VCH Verlag; ChemistrySelect; 2; 32; 13-11-2017; 10470-10475

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