Artículo
Calix[n]arenes: active organocatalysts for the synthesis of densely functionalized piperidines by one-pot multicomponent procedure
Palermo, Valeria
; Sathicq, Angel Gabriel
; Liberto, N.; Fernandes, S.; Langer, P.; Jios, Jorge Luis; Romanelli, Gustavo Pablo
Fecha de publicación:
03/2016
Editorial:
Elsevier
Revista:
Tetrahedron Letters
ISSN:
0040-4039
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
An efficient, suitable and high yielding method has been developed for the synthesis of different densely functionalized piperidine derivatives via pseudo-five component, one-pot domino reaction through a combination of β-ketoesters, aromatic aldehydes, and various amines using p-sulfonic acid calix[n]arenes as catalysts. The reaction was carried out in refluxing methanol, affording very good yields of the expected piperidine. Atomic economy, environmentally benign procedure, reuse of catalysts, and short reaction time are some of the important features of this protocol.
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Articulos(CINDECA)
Articulos de CENTRO DE INV EN CS.APLICADAS "DR.JORGE J.RONCO"
Articulos de CENTRO DE INV EN CS.APLICADAS "DR.JORGE J.RONCO"
Citación
Palermo, Valeria; Sathicq, Angel Gabriel; Liberto, N.; Fernandes, S.; Langer, P.; et al.; Calix[n]arenes: active organocatalysts for the synthesis of densely functionalized piperidines by one-pot multicomponent procedure; Elsevier; Tetrahedron Letters; 57; 19; 3-2016; 2049-2054
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