Artículo
Enhancement of dissolution rate of furosemide using a solid dispersion with D-Glucosamine HCl
Han, Yong Ki; Calvo, Romina G.; Faudone, Sonia Nerina; Zitto, Gustavo; Gorzalczany, Susana Beatriz; Wolfenson, Alberto Enrique
; Bonafede, Silvina; Rosasco, María Ana; Segall, Adriana Ines
Fecha de publicación:
08/2016
Editorial:
Bentham Science Publishers
Revista:
Current Pharmaceutical Analysis
ISSN:
1573-4129
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Furosemide is a potent high ceiling (loop) diuretic mainly used in the treatment of edematous states associated with cardiac, renal, and hepatic failure, and the treatment of hypertension. Furosemide has been classified as a class IV drug as per the biopharmaceutical classification system (BCS). D-Glucosamine HCl was used to increase the aqueous solubility of furosemide. The objective of the present work is to improve de dissolution profile of furosemide by formation of a physical mixture and a solid dispersion with D-glucosamine HCl. The solid dispersion was prepared by solvent method using acetone/water. The dissolution properties and physicochemical properties of furosemide: D-glucosamine HCl physical mixture and solid dispersion were investigated by dissolution test, X-ray diffractometry, infrared spectrometry, differential scanning calorimetry (DSC), microscopy (SEM) and 35Cl Nuclear Quadrupole Resonance (NQR). The diuretic activity was proved comparing the solid dispersion with pure furosemide. This study shows that the dissolution rate of furosemide can be enhanced considerably by formulating it with D-glucosamine HCl, as a physical mixture or as a solid dispersion although cristallinity was maintained. Solid dispersion and pure furosemide showed significant increase in diuresis in rats as compared to the control group.
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Articulos(IFEG)
Articulos de INST.DE FISICA ENRIQUE GAVIOLA
Articulos de INST.DE FISICA ENRIQUE GAVIOLA
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Han, Yong Ki; Calvo, Romina G.; Faudone, Sonia Nerina; Zitto, Gustavo; Gorzalczany, Susana Beatriz; et al.; Enhancement of dissolution rate of furosemide using a solid dispersion with D-Glucosamine HCl; Bentham Science Publishers; Current Pharmaceutical Analysis; 12; 3; 8-2016; 192-197
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