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dc.contributor.author
Lam, Daniel D.
dc.contributor.author
Attard, Courtney A.
dc.contributor.author
Mercer, Aaron J.
dc.contributor.author
Myers Jr, Martin G.
dc.contributor.author
Rubinstein, Marcelo
dc.contributor.author
Low, Malcolm J.
dc.date.available
2016-02-03T20:19:12Z
dc.date.issued
2015-01-16
dc.identifier.citation
Lam, Daniel D.; Attard, Courtney A.; Mercer, Aaron J.; Myers Jr, Martin G.; Rubinstein, Marcelo; et al.; Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism; Endocrine Society; Endocrinology; 156; 4; 16-1-2015; 1292-1302
dc.identifier.issn
0013-7227
dc.identifier.uri
http://hdl.handle.net/11336/4004
dc.description.abstract
Peptides derived from the proopiomelanocortin (POMC) precursor are critical for the normal regulation of many physiological parameters, and POMC deficiency results in severe obesity and metabolic dysfunction. Conversely, augmentation of central nervous system melanocortin function is a promising therapeutic avenue for obesity and diabetes but is confounded by detrimental cardiovascular effects including hypertension. Because the hypothalamic population of POMC-expressing neurons is neurochemically and neuroanatomically heterogeneous, there is interest in the possible dissociation of functionally distinct POMC neuron subpopulations. We used a Cre recombinase-dependent and hypothalamus-specific reactivatable PomcNEO allele to restrict Pomc expression to hypothalamic neurons expressing leptin receptor (Lepr) in mice. In contrast to mice with total hypothalamic Pomc deficiency, which are severely obese, mice with Lepr-restricted Pomc expression displayed fully normal body weight, food consumption, glucose homeostasis, and locomotor activity. Thus, Lepr+ POMC neurons, which constitute approximately two-thirds of the total POMC neuron population, are sufficient for normal regulation of these parameters. This functional dissociation approach represents a promising avenue for isolating therapeutically relevant POMC neuron subpopulations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Endocrine Society
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Receptor de Leptina
dc.subject
Pomc
dc.subject
Ratón Transgénico
dc.subject
Obesidad
dc.subject.classification
Endocrinología y Metabolismo
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
156
dc.journal.number
4
dc.journal.pagination
1292-1302
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Lam, Daniel D.. University of Michigan. Medical School. Division of Metabolism, Endocrinology, and Diabetes. Department of Molecular and Integrative Physiology; Estados Unidos
dc.description.fil
Fil: Attard, Courtney A.. University of Michigan. Medical School. Division of Metabolism, Endocrinology, and Diabetes. Department of Molecular and Integrative Physiology; Estados Unidos
dc.description.fil
Fil: Mercer, Aaron J.. University of Michigan. Medical School. Division of Metabolism, Endocrinology, and Diabetes. Department of Molecular and Integrative Physiology; Estados Unidos
dc.description.fil
Fil: Myers Jr, Martin G.. University of Michigan. Medical School. Division of Metabolism, Endocrinology, and Diabetes. Department of Internal Medicine; Estados Unidos
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. University of Michigan. Medical School. Division of Metabolism, Endocrinology, and Diabetes. Department of Molecular and Integrative Physiology; Estados Unidos
dc.description.fil
Fil: Low, Malcolm J.. University of Michigan. Medical School. Division of Metabolism, Endocrinology, and Diabetes. Department of Molecular and Integrative Physiology; Estados Unidos
dc.journal.title
Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://press.endocrine.org/doi/10.1210/en.2014-1373?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1210/en.2014-1373
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/0013-7227


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