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dc.contributor.author
Franchini, Lucia Florencia
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dc.contributor.author
Pollard, Katherine S.
dc.date.available
2016-02-03T20:15:39Z
dc.date.issued
2015-09
dc.identifier.citation
Franchini, Lucia Florencia; Pollard, Katherine S.; Genomic approaches to studying human-specific developmental traits; Company of Biologists; Development; 142; 9-2015; 3100-3112
dc.identifier.issn
0950-1991
dc.identifier.uri
http://hdl.handle.net/11336/4002
dc.description.abstract
Changes in developmental regulatory programs drive both disease and phenotypic differences among species. Linking human-specific traits to alterations in development is challenging, because we have lacked the tools to assay and manipulate regulatory networks in human and primate embryonic cells. This field was transformed by the sequencing of hundreds of genomes - human and non-human - that can be compared to discover the regulatory machinery of genes involved in human development. This approach has identified thousands of human-specific genome alterations in developmental genes and their regulatory regions. With recent advances in stem cell techniques, genome engineering, and genomics, we can now test these sequences for effects on developmental gene regulation and downstream phenotypes in human cells and tissues.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Company of Biologists
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dc.rights
info:eu-repo/semantics/embargoedAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Evolution
dc.subject
Humans
dc.subject
Brain
dc.subject
Primates
dc.subject.classification
Biología del Desarrollo
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Genomic approaches to studying human-specific developmental traits
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
142
dc.journal.pagination
3100-3112
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
dc.description.fil
Fil: Pollard, Katherine S.. Gladstone Institutes; Estados Unidos. University of California. Department of Epidemiology & Biostatistics. Institute for Human Genetics; Estados Unidos
dc.journal.title
Development
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dc.rights.embargoDate
2016-10-31
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/content/142/18/3100.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.1242/dev.120048
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/0950-1991
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