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dc.contributor.author
Palomar, Martín Manuel
dc.contributor.author
Bru Chauve, Elena Magdalena
dc.contributor.author
Maldonado Galdeano, María Carolina
dc.contributor.author
Perdigon, Gabriela del Valle
dc.date.available
2018-03-26T20:21:16Z
dc.date.issued
2017-06
dc.identifier.citation
Palomar, Martín Manuel; Bru Chauve, Elena Magdalena; Maldonado Galdeano, María Carolina; Perdigon, Gabriela del Valle; Oral probiotics supplementation can stimulate the immune system in a stress process; Elsevier Inc; Journal of Nutrition and Intermediary Metabolism; 8; 6-2017; 29-40
dc.identifier.issn
2352-3859
dc.identifier.uri
http://hdl.handle.net/11336/40027
dc.description.abstract
In a bifactorial stress mouse model we studied the effect of probiotic supplementation on biochemical parameter in serum, the intestinal impairment of the villi induced by stress, the systemic immune response and the susceptibility to intestinal infections. Probiotic effect was also evaluated on cells from the innate immunity. Mice were subjected to a stress protocol based on food deprivation and movement restrictions for 11 days. We analyzed the probiotic supplementation effect, as probiotic bacteria suspension or as a fermented milk, on the changes induced by stress: biochemical parameters as glucose, triglycerides and cholesterol in serum, body weight and in the gut we determined the number of goblet cells, the length of the microvilli and bacterial translocation from the intestinal microbiota into deep tissues. Peritoneal and spleen macrophages activity, the immune response to ovalbumin immunization, the protection against Salmonella infection during the stress process in mice receiving probiotic, were also determined. We found that probiotic supplementation in the chronic stress model, improves the gut histological structure, increases phagocytic activity of peritoneal and spleen macrophages, enhance the humoral response to the OVA antigen and protect against Salmonella infection. Conclusion: Probiotic supplementation was able to act on the gut and systemic immunity by improvement of the length and cellularity of the villi, increasing the systemic immune response and protecting against Salmonella infection. The effectiveness on the immune system exerted by probiotic consumption suggests the use of these bacteria as an alternative to minimize the damage induced during stress situation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Enteric Infection
dc.subject
Immune System Adjuvants
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Probiotics Supplementation
dc.subject
Stress
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Oral probiotics supplementation can stimulate the immune system in a stress process
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-26T18:15:48Z
dc.journal.volume
8
dc.journal.pagination
29-40
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Palomar, Martín Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Bru Chauve, Elena Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Maldonado Galdeano, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.journal.title
Journal of Nutrition and Intermediary Metabolism
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jnim.2017.06.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2352385916300275


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