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dc.contributor.author
Furtos, Gabriel  
dc.contributor.author
Rivero, Guadalupe  
dc.contributor.author
Rapuntean, Sorin  
dc.contributor.author
Abraham, Gustavo Abel  
dc.date.available
2018-03-26T18:55:50Z  
dc.date.issued
2017-07  
dc.identifier.citation
Furtos, Gabriel; Rivero, Guadalupe; Rapuntean, Sorin; Abraham, Gustavo Abel; Amoxicillin-loaded electrospun nanocomposite membranes for dental applications; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part B-applied Biomaterials; 105; 5; 7-2017; 966-976  
dc.identifier.issn
1552-4973  
dc.identifier.uri
http://hdl.handle.net/11336/39962  
dc.description.abstract
Electrospun nanocomposite matrices based on poly(ε-caprolactone) (PCL), nano-hydroxyapatite (nHAp) and amoxicillin (AMX) were designed and investigated for dental applications. nHAp provides good biocompatibility, bioactivity, osteoconductivity, and osteoinductivity properties, and AMX, as antibiotic model, controls and/or reduces bacterial contamination of periodontal defects while enhancing tissue regeneration. A series of polymeric nanocomposites was obtained by varying both the antibiotic and nHAp contents. Fibrous membranes of different compositions were obtained by electrospinning technique, and morphological, thermal, mechanical and surface properties were characterized. The incorporation of AMX seemed to alter the nHAp distribution within the microfibrous matrix. The interaction between AMX and nHAp affected the mechanical performance and modulated the antibiotic release behavior. AMX release profiles presented a burst release that depended on nHAp content, followed by a slow release stage where the drug content (85–100%) was released in 3 weeks. The antimicrobial activity of the AMX-loaded membranes was tested with four bacterial strains depended on both the drug and nHAp contents. Extensive mineralization in simulated body fluid (SBF) was evidenced by SEM/EDX analysis after 21 days. The studied electrospun nanocomposite amoxicillin-loaded membranes could be a promising fibrous-based antibiotic carrier system for dental and tissue engineering applications.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Antibacterial Activity  
dc.subject
Antibiotic Delivery  
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Electrospun Scaffolds  
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Mineralization  
dc.subject.classification
Biotecnología Industrial  
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Biotecnología Industrial  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Amoxicillin-loaded electrospun nanocomposite membranes for dental applications  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-26T18:05:04Z  
dc.journal.volume
105  
dc.journal.number
5  
dc.journal.pagination
966-976  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Furtos, Gabriel. Raluca Ripan Institute for Research in Chemistry; Rumania  
dc.description.fil
Fil: Rivero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina  
dc.description.fil
Fil: Rapuntean, Sorin. University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca; Rumania  
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina  
dc.journal.title
Journal of Biomedical Materials Research Part B-applied Biomaterials  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jbm.b.33629  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.33629