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Artículo

Heme-oxygenase-1 implications in cell morphology and the adhesive behavior of prostate cancer cells

Gueron, GeraldineIcon ; Giudice, JimenaIcon ; Valacco, Maria PiaIcon ; Paez, AlejandraIcon ; Elguero, María BelénIcon ; Toscani, Andrés MartinIcon ; Jaworski, Felipe MartínIcon ; Coluccio Leskow, FedericoIcon ; Cotignola, Javier HernanIcon ; Marti, Marcelo AdrianIcon ; Binaghi, MaríaIcon ; Navone, Nora; Vazquez, Elba SusanaIcon
Fecha de publicación: 03/2014
Editorial: Impact Journals
Revista: Oncotarget
ISSN: 1949-2553
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Prostate cancer (PCa) is the second leading cause of cancer death in men. Although previous studies in PCa have focused on cell adherens junctions (AJs), key players in metastasis, they have left the molecular mechanisms unexplored. Inflammation and the involvement of reactive oxygen species (ROS) are critical in the regulation of cell adhesion and the integrity of the epithelium. Heme oxygenase-1 (HO-1) counteracts oxidative and inflammatory damage. Here, we investigated whether HO-1 is implicated in the adhesive and morphological properties of tumor cells. Genes differentially regulated by HO-1 were enriched for cell motility and adhesion biological processes. HO-1 induction, increased E-cadherin and β-catenin levels. Immunofluorescence analyses showed a striking remodeling of E-cadherin/β-catenin based AJs under HO-1 modulation. Interestingly, the enhanced levels of E-cadherin and β-catenin coincided with a markedly change in cell morphology. To further our analysis we sought to identify HO-1 binding proteins that might participate in the regulation of cell morphology. A proteomics approach identified Muskelin, as a novel HO-1 partner, strongly implicated in cell morphology regulation. These results define a novel role for HO-1 in modulating the architecture of cell-cell interactions, favoring a less aggressive phenotype and further supporting its anti-tumoral function in PCa.
Palabras clave: ADHERENS JUNCTIONS , B-CATENIN , E-CADHERIN , HEME-OXYGENASE-1 , MUSKELIN , PROSTATE CANCER
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/39917
DOI: http://dx.doi.org/10.18632/oncotarget.1826
URL: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147308/
Colecciones
Articulos(INQUIMAE)
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
Gueron, Geraldine; Giudice, Jimena; Valacco, Maria Pia; Paez, Alejandra; Elguero, María Belén; et al.; Heme-oxygenase-1 implications in cell morphology and the adhesive behavior of prostate cancer cells; Impact Journals; Oncotarget; 5; 12; 3-2014; 4087-4102
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