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dc.contributor.author
Vogl, Annette M.
dc.contributor.author
Brockmann, Marisa M.
dc.contributor.author
Giusti, Sebastian Alejandro
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MacCarrone, Giuseppina
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Vercelli, Claudia Alejandra
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Bauder, Corinna A.
dc.contributor.author
Richter, Julia S.
dc.contributor.author
Roselli, Francesco
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Hafner, Anne-Sophie
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Dedic, Nina
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Wotjak, Carsten T.
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Vogt Weisenhorn, Daniela M.
dc.contributor.author
Choquet, Daniel
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Turck, Christoph W.
dc.contributor.author
Stein, Valentin
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Deussing, Jan M.
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Refojo, Damian
dc.date.available
2018-03-23T17:32:51Z
dc.date.issued
2015-02
dc.identifier.citation
Vogl, Annette M.; Brockmann, Marisa M.; Giusti, Sebastian Alejandro; MacCarrone, Giuseppina; Vercelli, Claudia Alejandra; et al.; Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition; Nature Publishing Group; Nature Neuroscience.; 18; 2; 2-2015; 239-251
dc.identifier.issn
1097-6256
dc.identifier.uri
http://hdl.handle.net/11336/39796
dc.description.abstract
Neddylation is a ubiquitylation-like pathway that controls cell cycle and proliferation by covalently conjugating Nedd8 to specific targets. However, its role in neurons, nonreplicating postmitotic cells, remains unexplored. Here we report that Nedd8 conjugation increased during postnatal brain development and is active in mature synapses, where many proteins are neddylated. We show that neddylation controls spine development during neuronal maturation and spine stability in mature neurons. We found that neddylated PSD-95 was present in spines and that neddylation on Lys202 of PSD-95 is required for the proactive role of the scaffolding protein in spine maturation and synaptic transmission. Finally, we developed Nae1 CamKIIα-CreERT2 mice, in which neddylation is conditionally ablated in adult excitatory forebrain neurons. These mice showed synaptic loss, impaired neurotransmission and severe cognitive deficits. In summary, our results establish neddylation as an active post-translational modification in the synapse regulating the maturation, stability and function of dendritic spines.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Neddylation
dc.subject
Dendritic Spines
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Synapses
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Ubiquitin Like Proteins
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-02T13:58:03Z
dc.journal.volume
18
dc.journal.number
2
dc.journal.pagination
239-251
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Vogl, Annette M.. Instituto Max Planck de Psiquiatria de Munich; Alemania
dc.description.fil
Fil: Brockmann, Marisa M.. Instituto Max Planck de Psiquiatria de Munich; Alemania
dc.description.fil
Fil: Giusti, Sebastian Alejandro. Instituto Max Planck de Psiquiatria de Munich; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: MacCarrone, Giuseppina. Instituto Max Planck de Psiquiatria de Munich; Alemania
dc.description.fil
Fil: Vercelli, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
dc.description.fil
Fil: Bauder, Corinna A.. Instituto Max Planck de Psiquiatria de Munich; Alemania
dc.description.fil
Fil: Richter, Julia S.. Instituto Max Planck de Psiquiatria de Munich; Alemania. Instituto Max Planck de Psiquiatria de Munich; Alemania
dc.description.fil
Fil: Roselli, Francesco. Universita Degli Studi Di Bari; Italia
dc.description.fil
Fil: Hafner, Anne-Sophie. Universite de Bordeaux; Francia
dc.description.fil
Fil: Dedic, Nina. Instituto Max Planck de Psiquiatria de Munich; Alemania
dc.description.fil
Fil: Wotjak, Carsten T.. Instituto Max Planck de Psiquiatria de Munich; Alemania
dc.description.fil
Fil: Vogt Weisenhorn, Daniela M.. Institute Of Developmental Genetics; Alemania
dc.description.fil
Fil: Choquet, Daniel. Universite de Bordeaux; Francia
dc.description.fil
Fil: Turck, Christoph W.. Instituto Max Planck de Psiquiatria de Munich; Alemania
dc.description.fil
Fil: Stein, Valentin. Universitaet Bonn; Alemania
dc.description.fil
Fil: Deussing, Jan M.. Instituto Max Planck de Psiquiatria de Munich; Alemania
dc.description.fil
Fil: Refojo, Damian. Instituto Max Planck de Psiquiatria de Munich; Alemania
dc.journal.title
Nature Neuroscience.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nn.3912
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nn.3912


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