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dc.contributor.author
Garay, Arturo
dc.contributor.author
Cardinali, Daniel Pedro
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dc.date.available
2018-03-23T15:29:45Z
dc.date.issued
2016-07
dc.identifier.citation
Garay, Arturo; Cardinali, Daniel Pedro; New concepts in the neurophysiology of sleep and wakefulness; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 9; 3; 7-2016; 26-36
dc.identifier.uri
http://hdl.handle.net/11336/39773
dc.description.abstract
The neural substrates of sleep and wakefulness form a highly distributed and, to some extent, redundant network, with hypocretin, monoaminergic and cholinergic systems largely promoting wakefulness and GABAergic systems in the preoptic area, hypothalamus and brainstem promoting sleep. The hypocretin/orexin system plays a special role in the promotion of wakefulness and suppression of REM sleep by providing excitatory input to the monoaminergic and cholinergic systems. Sleep is not a unitary state but involves a cyclic alternation between NREM and REM sleep; the pons is critical for generating the multiple components (ie, EEG synchronization, eye movements and muscle atonia) that characterize REM sleep. Recent findings have implicated the participation of hypothalamus, through MCH/GABA that provide a critical input to pontine generator of REM sleep. The timing of sleep and wakefulness is regulated by an interaction between the circadian pacemaker located in the hypothalamic SCN and a sleep homeostatic system whose anatomic location is yet to be definitively identified. Among various neurochemicals, extracellular AD and nNOS/NK1 accumulate in the BF as wakefulness is extended and inhibits cortically projecting cholinergic neurons, thereby influencing cortical activity. In the future, it seems reasonable to expect a spreading of these insights from basic to clinical grounds for a better understanding of the causes and mechanisms of sleep disorders and the generation of novel therapeutics in sleep medicine.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sociedad Argentina de Fisiología
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Rem
dc.subject
Nrem
dc.subject
Monoaminergic
dc.subject
Cholinergic And Gabaergic Systems
dc.subject
Hypocretin
dc.subject
Hypothalamus
dc.subject
Circadian Pacemaker
dc.subject
Atonia
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
New concepts in the neurophysiology of sleep and wakefulness
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-20T14:34:04Z
dc.identifier.eissn
1669-5410
dc.journal.volume
9
dc.journal.number
3
dc.journal.pagination
26-36
dc.journal.pais
Argentina
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dc.journal.ciudad
Ciudad Autónoma de Buenos Aires
dc.description.fil
Fil: Garay, Arturo. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
dc.description.fil
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
Physiological Mini Reviews
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/85
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