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dc.contributor.author | Grasso, Ernesto Javier![]() |
dc.contributor.author | Oliveira, Rafael Gustavo![]() |
dc.contributor.author | Maggio, Bruno![]() |
dc.date.available | 2018-03-23T15:25:46Z |
dc.date.issued | 2016-02-15 |
dc.identifier.citation | Grasso, Ernesto Javier; Oliveira, Rafael Gustavo; Maggio, Bruno; Surface interactions, thermodynamics and topography of binary monolayers of Insulin with dipalmitoylphosphatidylcholine and 1-palmitoyl-2-oleoylphosphatidylcholine at the air/water interface; Academic Press Inc Elsevier Science; Journal of Colloid and Interface Science; 464; 15-2-2016; 264-276 |
dc.identifier.issn | 0021-9797 |
dc.identifier.uri | http://hdl.handle.net/11336/39769 |
dc.description.abstract | The molecular packing, thermodynamics and surface topography of binary Langmuir monolayers of Insulin and DPPC (dipalmitoylphosphatidylcholine) or POCP (1-palmitoyl-2-oleoylphosphatidylcholine) at the air/water interface on Zn2+ containing solutions were studied. Miscibility and interactions were ascertained by the variation of surface pressure-mean molecular area isotherms, surface compressional modulus and surface (dipole) potential with the film composition. Brewster Angle Microscopy was used to visualize the surface topography of the monolayers. Below 20mN/m Insulin forms stable homogenous films with DPPC and POPC at all mole fractions studied (except for films with XINS=0.05 at 10mN/m where domain coexistence was observed). Above 20mN/m, a segregation process between mixed phases occurred in all monolayers without squeezing out of individual components. Under compression the films exhibit formation of a viscoelastic or kinetically trapped organization leading to considerable composition-dependent hysteresis under expansion that occurs with entropic-enthalpic compensation. The spontaneously unfavorable interactions of Insulin with DPPC are driven by favorable enthalpy that is overcome by unfavorable entropic ordering; in films with POPC both the enthalpic and entropic effects are unfavorable. The surface topography reveals domain coexistence at relatively high pressure showing a striped appearance. The interactions of Insulin with two major membrane phospholipids induces composition-dependent and long-range changes of the surface organization that ought to be considered in the context of the information-transducing capabilities of the hormone for cell functioning. |
dc.format | application/pdf |
dc.language.iso | eng |
dc.publisher | Academic Press Inc Elsevier Science![]() |
dc.rights | info:eu-repo/semantics/restrictedAccess |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.subject | 1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE (POPC) |
dc.subject | BINARY MONOLAYERS |
dc.subject | DIPALMITOYLPHOSPHATIDYLCHOLINE (DPPC) |
dc.subject | HYSTERESIS |
dc.subject | INSULIN |
dc.subject | INSULIN SURFACE BEHAVIOR |
dc.subject | LANGMUIR MONOLAYERS |
dc.subject.classification | Otras Ciencias Biológicas![]() |
dc.subject.classification | Ciencias Biológicas![]() |
dc.subject.classification | CIENCIAS NATURALES Y EXACTAS![]() |
dc.title | Surface interactions, thermodynamics and topography of binary monolayers of Insulin with dipalmitoylphosphatidylcholine and 1-palmitoyl-2-oleoylphosphatidylcholine at the air/water interface |
dc.type | info:eu-repo/semantics/article |
dc.type | info:ar-repo/semantics/artículo |
dc.type | info:eu-repo/semantics/publishedVersion |
dc.date.updated | 2018-03-07T18:39:54Z |
dc.journal.volume | 464 |
dc.journal.pagination | 264-276 |
dc.journal.pais | Estados Unidos![]() |
dc.journal.ciudad | New York |
dc.description.fil | Fil: Grasso, Ernesto Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina |
dc.description.fil | Fil: Oliveira, Rafael Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina |
dc.description.fil | Fil: Maggio, Bruno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina |
dc.journal.title | Journal of Colloid and Interface Science![]() |
dc.relation.alternativeid | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jcis.2015.11.034 |
dc.relation.alternativeid | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0021979715303441 |
dc.conicet.fuente | individual |