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dc.contributor.author
Urquiza, Nora María  
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Naso, Luciana Gissella  
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Martínez Medina, Juan José  
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Moyano, Maria Alejandra  
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Lezama, Luis Raul  
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Williams, Patricia Ana María  
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Ferrer, Evelina Gloria  
dc.date.available
2018-03-23T14:00:06Z  
dc.date.issued
2016-04  
dc.identifier.citation
Urquiza, Nora María; Naso, Luciana Gissella; Martínez Medina, Juan José; Moyano, Maria Alejandra; Lezama, Luis Raul; et al.; Pharmacological activities of a propylthiouracil compound structurally modified by coordination with copper(II); Taylor & Francis Ltd; Journal of Coordination Chemistry; 69; 8; 4-2016; 1293-1312  
dc.identifier.issn
0095-8972  
dc.identifier.uri
http://hdl.handle.net/11336/39741  
dc.description.abstract
For the first time, pharmacological activities for propylthiouracil (actually used as antithyroid drug) were determined. In addition, a new propylthiouracil copper(II) complex ([Cu(PTU)2]2) was synthesized and characterized by FTIR, EPR, UV-visible, and diffuse reflectance spectroscopies including elemental analysis, dissolution profiles, and stability studies. Taking into account the correlation between Graves disease and the formation of reactive oxygen species (ROS) and other free radicals, the ligand and the complex were tested for their antioxidant effects on O2 ·- and OH· radicals. A significant increase in the disruption of OH· radical was observed for PTU and its copper(II) complex, but neither of them have the ability to dismutate the O2 ·- radical. Antimicrobial activities were also determined observing that the complex is very active against Gram-positive bacteria. In addition, the ability of PTU and its complex to inhibit acid and alkaline phosphatases were analyzed. Results showed that PTU had no effect, while the complex behaved as a potent ALP (alkaline phosphatases) inhibitor. Finally, albumin interaction experiments denoted high affinity towards the complex in contrast with PTU with a constant binding value two hundred times higher than the ligand and bearing two binding sites. Based on this study, it has been hypothesized that ([Cu(PTU)2]2 would be a promising candidate for further evaluation as an antioxidant, antimicrobial and phosphatase alkaline inhibitor agent.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Antimicrobial Activity  
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Antioxidants  
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Bsa Interactions  
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Copper(Ii)  
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Propylthiouracil  
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Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Pharmacological activities of a propylthiouracil compound structurally modified by coordination with copper(II)  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
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info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-20T13:20:49Z  
dc.journal.volume
69  
dc.journal.number
8  
dc.journal.pagination
1293-1312  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Urquiza, Nora María. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; Argentina  
dc.description.fil
Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina  
dc.description.fil
Fil: Martínez Medina, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina  
dc.description.fil
Fil: Moyano, Maria Alejandra. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Analitica; Argentina  
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Fil: Lezama, Luis Raul. Universidad del País Vasco; España  
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Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina  
dc.description.fil
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina  
dc.journal.title
Journal of Coordination Chemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/00958972.2016.1167885  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/00958972.2016.1167885