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dc.contributor.author
Liaudat, Ana Cecilia
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Rodríguez, N.
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Chen, S.
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Romanini, María Cristina
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Vivas, A.
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Rolando, A.
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Gauna, H.
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Mayer, N.
dc.date.available
2018-03-22T17:50:48Z
dc.date.issued
2015-08
dc.identifier.citation
Liaudat, Ana Cecilia; Rodríguez, N.; Chen, S.; Romanini, María Cristina; Vivas, A.; et al.; Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation; Informa Healthcare; Biotechnic and Histochemistry; 90; 6; 8-2015; 432-438
dc.identifier.issn
1052-0295
dc.identifier.uri
http://hdl.handle.net/11336/39704
dc.description.abstract
Stress in pregnant rats caused by chronic immobilization alters the pattern of secretion of corticosterone and modifies the hypothalamic-pituitary-adrenal axis (HPA) of the fetus. Early postnatal handling, however, may reverse the effects of increased secretion of corticosterone. We investigated the effects of prenatal stress and postnatal handling on the activity of the HPA axis of male offspring of stressed female rats. Male 90-day-old rats from four groups were investigated: prenatally stressed animals without postnatal handling, prenatally stressed animals with postnatal handling, unstressed control animals with postnatal handling, and unstressed control animals without postnatal handling. After sacrifice, the adrenal glands were weighed to determine the adrenal-somatic index. Apoptosis was evaluated by TUNEL assay and active caspase-3 expression. We found that the adrenal gland cortex:medulla ratio increased in animals with prenatal stress and that eventually the stress caused apoptosis. Handling newborns to simulate maternal activity ameliorated some of the negative effects of prenatal stress.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Informa Healthcare
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Adrenal Gland
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Apoptosis
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Handling
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Hypothalamic-Pituitary-Adrenal Axis
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Immobilization
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Prenatal Stress
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Rats
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Adrenal response of male rats exposed to prenatal stress and early postnatal stimulation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-22T13:04:17Z
dc.journal.volume
90
dc.journal.number
6
dc.journal.pagination
432-438
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Liaudat, Ana Cecilia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Rodríguez, N.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
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Fil: Chen, S.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
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Fil: Romanini, María Cristina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Vivas, A.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
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Fil: Rolando, A.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Gauna, H.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Mayer, N.. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.journal.title
Biotechnic and Histochemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/10520295.2015.1019926
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info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/10520295.2015.1019926
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