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Artículo

The Rheological Properties of Lipid Monolayers Modulate the Incorporation of l -Ascorbic Acid Alkyl Esters

Zulueta Díaz, Yenisleidy de Las MercedesIcon ; Mottola, MilagroIcon ; Vico, Raquel VivianaIcon ; Fanani, Maria LauraIcon
Fecha de publicación: 01/2016
Editorial: American Chemical Society
Revista: Langmuir
ISSN: 0743-7463
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

In this work, we tested the hypothesis that the incorporation of amphiphilic drugs into lipid membranes may be regulated by their rheological properties. For this purpose, two members of the l-ascorbic acid alkyl esters family (ASCn) were selected, ASC16 and ASC14, which have different rheological properties when organized at the air/water interface. They are lipophilic forms of Vitamin C used in topical pharmacological preparations. The effect of the phase state of the host lipid membranes on ASCn incorporation was explored using Langmuir monolayers. Films of pure lipids with known phase states have been selected, showing liquid-expanded, liquid-condensed, and solid phases as well as pure cholesterol films in liquid-ordered state. We also tested ternary and quaternary mixed films that mimic the properties of cholesterol containing membranes and of the stratum corneum. The compressibility and shear properties of those monolayers were assessed in order to define its phase character. We found that the length of the acyl chain of the ASCn compounds induces differential changes in the rheological properties of the host membrane and subtly regulates the kinetics and extent of the penetration process. The capacity for ASCn uptake was found to depend on the phase state of the host film. The increase in surface pressure resultant after amphiphile incorporation appears to be a function of the capacity of the host membrane to incorporate such amphiphile as well as the rheological response of the film. Hence, monolayers that show a solid phase state responded with a larger surface pressure increase to the incorporation of a comparable amount of amphiphile than liquid-expanded ones. The cholesterol-containing films, including the mixture that mimics stratum corneum, allowed a very scarce ASCn uptake independently of the membrane diffusional properties. This suggests an important contribution of Cho on the maintenance of the barrier function of stratum corneum.
Palabras clave: Ascorbyl Palmitate , Langmuir Monolayers , Drug-Membrane Interaction , Lipid Monolayer Penetration , Stratum Corneum Lipids
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/39689
URL: http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.5b04175
DOI: http://dx.doi.org/10.1021/acs.langmuir.5b04175
Colecciones
Articulos(CIQUIBIC)
Articulos de CENTRO DE INVEST.EN QCA.BIOL.DE CORDOBA (P)
Articulos(IIBYT)
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Zulueta Díaz, Yenisleidy de Las Mercedes; Mottola, Milagro; Vico, Raquel Viviana; Fanani, Maria Laura; The Rheological Properties of Lipid Monolayers Modulate the Incorporation of l -Ascorbic Acid Alkyl Esters; American Chemical Society; Langmuir; 32; 2; 1-2016; 587-595
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