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dc.contributor.author
Venugopala, Katharigatta N.  
dc.contributor.author
Nayak, Susanta K.  
dc.contributor.author
Gleiser, Raquel M.  
dc.contributor.author
Sánchez, Mariela Eugenia  
dc.contributor.author
Garcia, Daniel Asmed  
dc.contributor.author
Odhav, Bharti  
dc.date.available
2018-03-22T16:41:03Z  
dc.date.issued
2016-07  
dc.identifier.citation
Venugopala, Katharigatta N.; Nayak, Susanta K.; Gleiser, Raquel M.; Sánchez, Mariela Eugenia; Garcia, Daniel Asmed; et al.; Synthesis, Polymorphism, and Insecticidal Activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate Against Anopheles arabiensis Mosquito; Wiley Blackwell Publishing, Inc; Chemical Biology & Drug Design; 88; 1; 7-2016; 88-96  
dc.identifier.issn
1747-0277  
dc.identifier.uri
http://hdl.handle.net/11336/39667  
dc.description.abstract
Mosquitoes are the major vectors of pathogens and parasites including those causing malaria, the most deadly vector-borne disease. The negative environmental effects of most synthetic compounds combined with widespread development of insecticide resistance encourage an interest in finding and developing alternative products against mosquitoes. In this study, pyrimido[2,1-b]quinazoline derivative DHPM3 has been synthesized by three-step chemical reaction and screened for larvicide, adulticide, and repellent properties against Anopheles arabiensis, one of the dominant vectors of malaria in Africa. The title compound emerged as potential larvicide agent for further research and development, because it exerted 100% mortality, while adulticide activity was considered moderate.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Antimosquito Properties  
dc.subject
Crystallography  
dc.subject
Polymorphism  
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Pyrimido[2,1-B]Quinazoline  
dc.subject
Synthesis  
dc.subject.classification
Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Synthesis, Polymorphism, and Insecticidal Activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate Against Anopheles arabiensis Mosquito  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-21T16:28:00Z  
dc.journal.volume
88  
dc.journal.number
1  
dc.journal.pagination
88-96  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Venugopala, Katharigatta N.. Durban University Of Technology; Sudáfrica  
dc.description.fil
Fil: Nayak, Susanta K.. Visvesvaraya National Institute of Technology; India  
dc.description.fil
Fil: Gleiser, Raquel M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina  
dc.description.fil
Fil: Sánchez, Mariela Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina  
dc.description.fil
Fil: Garcia, Daniel Asmed. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina  
dc.description.fil
Fil: Odhav, Bharti. Durban University Of Technology; Sudáfrica  
dc.journal.title
Chemical Biology & Drug Design  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/cbdd.12736  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.12736