Artículo
Yacon roots (Smallanthus sonchifolius) improve oxidative stress in diabetic rats
Habib, Natalia Cecilia
; Serra Barcellona, Carolina
; Honore, Stella Maris
; Genta, Susana Beatriz de Fátima; Sanchez, Sara Serafina del V.
Fecha de publicación:
08/2015
Editorial:
Taylor
Revista:
Pharmaceutical Biology
ISSN:
1388-0209
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Context: Smallanthus sonchifolius (Poepp. and Endl.) H. Robinson, Asteraceae (yacon) roots are a natural product recognized by the traditional medicine to treat diabetes-related problems. There are no reports concerning the potential of yacon roots to reduce oxidative stress and ameliorate diabetes complications in diabetic animals. Objective: This work analyzes the in vivo antioxidant activity and beneficial effects of yacon roots, using a model of streptozotocin-induced diabetes in rats. Materials and methods: Lipid peroxidation and other indicators of oxidative stress were determined in liver and kidney homogenates from non-diabetic rats, untreated diabetic rats, and diabetic rats treated orally with yacon flour (340 mg fructooligosaccharide/kg/d) as a diet supplement for 90 d. Biochemical parameters were determined in liver, kidney, and blood at the end of the experimental period. Results: Yacon supplementation to diabetic rats produced a significant decrease in malondialdehyde levels in both liver (-30.97%) and kidney (-19.15%). Hepatic superoxide dismutase and catalase activities were significantly lower in diabetic-treated rats (-13.46 and-64.33%, respectively) compared with diabetic controls. Similar results were observed in kidney. The treatment of diabetic rats produced an increase of glutathione peroxidase and glutathione levels in liver (172.50 and 35.91%, respectively) and kidney (177.78 and 57.76%, respectively). Plasma cholesterol and triacylglycerol levels and liver fatty acid composition, which were altered in diabetic rats, reverted back to nearly normal with yacon treatment. Conclusions: These results indicate that yacon root flour is a potential diet supplement with high in vivo antioxidant activity.
Palabras clave:
Andean Tubers
,
Antihyperlipidemic
,
Antioxidant
,
Diabetes
,
Fatty Acids
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Habib, Natalia Cecilia; Serra Barcellona, Carolina; Honore, Stella Maris; Genta, Susana Beatriz de Fátima; Sanchez, Sara Serafina del V.; Yacon roots (Smallanthus sonchifolius) improve oxidative stress in diabetic rats; Taylor; Pharmaceutical Biology; 53; 8; 8-2015; 1183-1193
Compartir
Altmétricas