Artículo
Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A
Di Ianni, Mauricio Emiliano
; del Valle, Maria Eugenia
; Enrique, Andrea Verónica
; Rosella, Maria Adelaida; Bruno, Fiorella; Bruno Blanch, Luis Enrique; Talevi, Alan
Fecha de publicación:
07/2015
Editorial:
Mary Ann Liebert
Revista:
Assay and Drug Development Technologies
ISSN:
1540-658X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested that the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model maximal electroshock seizure (MES) test. Thus, aqueous infusion from S. rebaudiana was tested in the MES test (mice, intraperitoneal administration), confirming dose-dependent anticonvulsant effect. Afterward, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, this article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications for food constituents and natural products.
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Di Ianni, Mauricio Emiliano; del Valle, Maria Eugenia; Enrique, Andrea Verónica; Rosella, Maria Adelaida; Bruno, Fiorella; et al.; Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A; Mary Ann Liebert; Assay and Drug Development Technologies; 13; 6; 7-2015; 313-318
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