Artículo
A whole genome bioinformatic approach to determine potential latent phase specific targets in Mycobacterium tuberculosis
Defelipe, Lucas Alfredo
; Fernández Do Porto, Darío Augusto
; Pereira Ramos, Pablo Ivan; Nicolás, Marisa Fabiana; Sosa, Ezequiel
; Radusky, Leandro Gabriel
; Lanzarotti, Esteban Omar
; Turjanski, Adrian
; Marti, Marcelo Adrian
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Fecha de publicación:
03/2016
Editorial:
Elsevier
Revista:
Tuberculosis (Edinb)
ISSN:
1472-9792
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Current Tuberculosis treatment is long and expensive, faces the increasing burden of MDR/XDR strains and lack of effective treatment against latent form, resulting in an urgent need of new anti-TB drugs. Key to TB biology is its capacity to fight the host's RNOS mediated attack. RNOS are known to display a concentration dependent mycobactericidal activity, which leads to the following hypothesis "if we know which proteins are targeted by RNOS and kill TB, we we might be able to inhibit them with drugs resulting in a synergistic bactericidal effect". Based on this idea, we performed an Mtb metabolic network whole proteome analysis of potential RNOS sensitive and relevant targets which includes target druggability and essentiality criteria. Our results, available at http://tuberq.proteinq.com.ar yield new potential TB targets, like I3PS, while also providing and updated view of previous proposals becoming an important tool for researchers looking for new ways of killing TB.
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Articulos(INQUIMAE)
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
Defelipe, Lucas Alfredo; Fernández Do Porto, Darío Augusto; Pereira Ramos, Pablo Ivan; Nicolás, Marisa Fabiana; Sosa, Ezequiel; et al.; A whole genome bioinformatic approach to determine potential latent phase specific targets in Mycobacterium tuberculosis; Elsevier; Tuberculosis (Edinb); 97; 3-2016; 181-192
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