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dc.contributor.author Fanovich, Maria Alejandra
dc.contributor.author Ivanovic, J.
dc.contributor.author Zizovic, I.
dc.contributor.author Misic, D.
dc.contributor.author Jaeger, P.
dc.date.available 2018-03-22T15:19:06Z
dc.date.issued 2016-01
dc.identifier.citation Fanovich, Maria Alejandra; Ivanovic, J.; Zizovic, I.; Misic, D.; Jaeger, P.; Functionalization of polycaprolactone/hydroxyapatite scaffolds with Usnea lethariiformis extract by using supercritical CO2; Elsevier Science; Materials Science and Engineering: C; 58; 1-2016; 204-212
dc.identifier.issn 0928-4931
dc.identifier.uri http://hdl.handle.net/11336/39635
dc.description.abstract Investigation of an integrated supercritical fluid extraction and supercritical solvent impregnation process for fabrication of microporous polycaprolactone-hydroxyapatite (PCL-HA) scaffolds with antibacterial activity is presented. The HA content and particle size as well as the operating conditions of the integrated process is optimized regarding the amount of impregnated antibacterial agent (Usnea lethariiformis extract) in the PCL-HA matrix, scaffold morphology and antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) strains. High pressure differential scanning calorimetry (HP-DSC) assay reveals that an increasing amount of HA results in decreasing melting temperature as well as crystallinity at an operating pressure of 17 MPa. The PCL-HA composites with micrometric sizes of the HA particles are convenient for being processed by the integrated process due to the simple preparation, a good interaction between the PCL matrix and filler and the advantageous impact on sorption. The scaffold obtained from PCL-HA with 20% of the HA shows the highest impregnation yield at 17 MPa and 35 °C (5.9%) and subsequently also the best bactericidal effect on the tested MRSA strains at an initial bacterial inoculum of 2 × 10- 4 CFU/mL.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject SCAFFOLDS
dc.subject POLYCAPROLACTONE
dc.subject SUPERCRITICAL FLUID
dc.subject.classification Recubrimientos y Películas
dc.subject.classification Ingeniería de los Materiales
dc.subject.classification INGENIERÍAS Y TECNOLOGÍAS
dc.title Functionalization of polycaprolactone/hydroxyapatite scaffolds with Usnea lethariiformis extract by using supercritical CO2
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-03-21T16:03:22Z
dc.journal.volume 58
dc.journal.pagination 204-212
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil Fil: Ivanovic, J.. University of Belgrade; Serbia
dc.description.fil Fil: Zizovic, I.. University of Belgrade; Serbia
dc.description.fil Fil: Misic, D.. University of Belgrade; Serbia
dc.description.fil Fil: Jaeger, P.. Universitat Hamburg; Alemania
dc.journal.title Materials Science and Engineering: C
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.msec.2015.08.024
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493115302794
dc.conicet.fuente individual


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    Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)