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dc.contributor.author
Gao, Haixiao
dc.contributor.author
Ayub, Maximiliano Juri
dc.contributor.author
Levin, Mariano Jorge
dc.contributor.author
Frank, Joachim
dc.date.available
2018-03-20T18:57:54Z
dc.date.issued
2005-07
dc.identifier.citation
Gao, Haixiao; Ayub, Maximiliano Juri; Levin, Mariano Jorge; Frank, Joachim; The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 102; 29; 7-2005; 10206-10211
dc.identifier.issn
0027-8424
dc.identifier.uri
http://hdl.handle.net/11336/39400
dc.description.abstract
We present analysis, by cryo-electron microscopy and single-particle reconstruction, of the structure of the 80S ribosome from Trypanosoma cruzi, the kinetoplastid protozoan pathogen that causes Chagas disease. The density map of the T. cruzi 80S ribosome shows the phylogenetically conserved eukaryotic rRNA core structure, together with distinctive structural features in both the small and large subunits. Remarkably, a previously undescribed helical structure appears in the small subunit in the vicinity of the mRNA exit channel. We propose that this rRNA structure likely participates in the recruitment of ribosome onto the 5′ end of mRNA, in facilitating and modulating the initiation of translation that is unique to the trypanosomes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
National Academy of Sciences
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Eukaryote
dc.subject
Initiation
dc.subject
Translation
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-15T18:03:33Z
dc.identifier.eissn
1091-6490
dc.journal.volume
102
dc.journal.number
29
dc.journal.pagination
10206-10211
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Gao, Haixiao. Howard Hughes Medical Institute; Estados Unidos
dc.description.fil
Fil: Ayub, Maximiliano Juri. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Levin, Mariano Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Frank, Joachim. State University of New York; Estados Unidos. Howard Hughes Medical Institute; Estados Unidos
dc.journal.title
Proceedings of the National Academy of Sciences of The United States of America
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/102/29/10206.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1073/pnas.0500926102
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