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dc.contributor.author
Birnbaumer, Lutz
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dc.date.available
2018-03-20T18:05:17Z
dc.date.issued
2015-09
dc.identifier.citation
Birnbaumer, Lutz; From GTP and G proteins to TRPC channels: a personal account; Springer; Journal of Molecular Medicine (Berlin, Germany); 93; 9; 9-2015; 941-953
dc.identifier.issn
0946-2716
dc.identifier.uri
http://hdl.handle.net/11336/39384
dc.description.abstract
By serendipity and good fortune, as a postdoctoral fellow in 1967, I landed at the right place at the right time, as I was allowed to investigate the mechanism by which hormones activate the enzyme adenylyl cyclase (then adenyl cyclase) in Martin Rodbell’s Laboratory at the NIH in Bethesda, Maryland. The work uncovered first, the existence of receptors separate from the enzyme and then, the existence of transduction mechanisms requiring guanosine-5′-triphosphate (GTP) and Mg2+. With my laboratory colleagues first and postdoctoral fellows after leaving NIH, I participated in the development of the field “signal transduction by G proteins,” uncovered by molecular cloning several G-protein-coupled receptors (GPCRs) and became interested in both the molecular makeup of voltage-gated Ca channels and Ca2+ homeostasis downstream of activation of phospholipase C (PLC) by the Gq/11 signaling pathway. We were able to confirm the hypothesis that there would be mammalian homologues of the Drosophila “transient receptor potential” channel and discovered the existence of six of the seven mammalian genes, now called transient receptor potential canonical (TRPC) channels. In the present article, I summarize from a bird’s eye view of what I feel were key findings along this path, not only from my laboratory but also from many others, that allowed for the present knowledge of cell signaling involving G proteins to evolve. Towards the end, I summarize roles of TRPC channels in health and disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ca Signaling
dc.subject
G Protein-Coupled Receptor
dc.subject
G Proteins
dc.subject
Gtpase
dc.subject
Transient Receptor Potential Channel
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
From GTP and G proteins to TRPC channels: a personal account
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-20T14:42:16Z
dc.identifier.eissn
1432-1440
dc.journal.volume
93
dc.journal.number
9
dc.journal.pagination
941-953
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina. National Institute of Environmental Research; Estados Unidos
dc.journal.title
Journal of Molecular Medicine (Berlin, Germany)
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00109-015-1328-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00109-015-1328-5
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