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Artículo

Insect Larvae: A new platform to produce commercial recombinant proteins

Targovnik, Alexandra MarisaIcon ; Arregui, Mariana BernadettIcon ; Bracco, Lautaro FidelIcon ; Urtasun, NicolásIcon ; Baieli, María FernandaIcon ; Segura, María Mercedes; Simonella, María A.; Fogar, Mariela A.; Wolman, Federico JavierIcon ; Cascone, OsvaldoIcon ; Miranda, Maria VictoriaIcon
Fecha de publicación: 03/2016
Editorial: Bentham Science Publishers
Revista: Current Pharmaceutical Biotechnology
ISSN: 1389-2010
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Farmacología y Farmacia

Resumen

In Biotechnology, the expression of recombinant proteins is a constantly growing field and different hosts are used for this purpose. Some valuable proteins cannot be produced using traditional systems. Insects from the order Lepidoptera infected with recombinant baculovirus have appeared as a good choice to express high levels of proteins, especially those with post-translational modifications.Lepidopteran insects, which are extensively distributed in the world, can be used as small protein factories, the new biofactories. Species like Bombyx mori (silkworm) have been analyzed in Asian countries to produce a great number of recombinant proteins for use in basic and applied science and industry. Many proteins expressed in this larva have been commercialized. Several recombinant proteins produced in silkworms have already been commercialized. On the otherhand, species like Spodoptera frugiperda, Heliothis virescens, Rachiplusia nu, Helicoverpa zea and Trichoplusia ni are widely distributed in both the occidental world and Europe. The expression of recombinant proteins in larvae has the advantage of its low cost in comparison with insect cell cultures. A wide variety of recombinant proteins, including enzymes, hormones and vaccines, have been efficiently expressed with intact biological activity. The expression of pharmaceutically proteins, using insect larvae or cocoons, has become very attractive. This review describes the use of insect larvae as an alternative to produce commercial recombinant proteins.
Palabras clave: Insect Larvae , Biofactories , Recombinant Proteins , Baculovirus
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/39372
URL: http://benthamscience.com/journals/current-pharmaceutical-biotechnology/volume/1
DOI: http://dx.doi.org/10.2174/138920101705160303163947
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Articulos(NANOBIOTEC)
Articulos de INSTITUTO DE NANOBIOTECNOLOGIA
Citación
Targovnik, Alexandra Marisa; Arregui, Mariana Bernadett; Bracco, Lautaro Fidel; Urtasun, Nicolás; Baieli, María Fernanda; et al.; Insect Larvae: A new platform to produce commercial recombinant proteins; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 17; 5; 3-2016; 431-438
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