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dc.contributor.author
Cardinali, Daniel Pedro
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dc.contributor.author
Escames, Germaine
dc.contributor.author
Acuña Castroviejo, Darío
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Ortiz, Francisco
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dc.contributor.author
Fernández Gil, Beatriz
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Guerra Librero, Ana
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García López, Sergio
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Shen, Ying
dc.contributor.author
Florido, Javier
dc.date.available
2018-03-19T22:48:37Z
dc.date.issued
2016-02
dc.identifier.citation
Cardinali, Daniel Pedro; Escames, Germaine; Acuña Castroviejo, Darío; Ortiz, Francisco; Fernández Gil, Beatriz; et al.; Melatonin-Induced Oncostasis, Mechanisms and Clinical Relevance; OMICS International; Journal of Integrative Oncology; 01; s1; 2-2016; 1-25
dc.identifier.issn
2329-6771
dc.identifier.uri
http://hdl.handle.net/11336/39328
dc.description.abstract
Melatonin is a natural substance ubiquitously distributed and present in almost all living species, from unicellular organisms to humans. Melatonin is synthesized not only in the pineal gland but also in most tissues in the body where it may have a cytoprotective function via paracrine or autocrine effects. Melatonin is effective in suppressing neoplastic growth in a variety of tumors. The mechanisms involved include antiproliferative effects via modulation of cell cycle, ability to induce apoptosis in cancer cells, anti-angiogenic and antimetastatic effects, anti-estrogenic activity, the capacity to decrease telomerase activity, immune modulation, and direct and indirect antioxidant effects. Besides these oncostatic properties, melatonin deserves to be considered in the treatment of cancer for two other reasons. First, because its hypnotic-chronobiotic properties, melatonin use that can allow the clinician to effectively address sleep disturbances, a major co-morbidity in cancer. Second, because melatonin’s anxiolytic and antidepressant effects, it has a possible application in two other major co-morbidities seen in cancer patients, i.e. depression and anxiety. This report summarizes the possible mechanisms involved in melatonin oncostasis and reviews what is known about the clinical application of melatonin as an adjuvant therapy in cancer patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
OMICS International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Melatonin
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Cancer
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Apoptosis
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Antioxidant
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Estrogen Signaling Pathway
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Metastasis
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Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Melatonin-Induced Oncostasis, Mechanisms and Clinical Relevance
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-19T17:27:29Z
dc.journal.volume
01
dc.journal.number
s1
dc.journal.pagination
1-25
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina ; Argentina
dc.description.fil
Fil: Escames, Germaine. Universidad de Granada; España
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Fil: Acuña Castroviejo, Darío. Universidad de Granada; España
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Fil: Ortiz, Francisco. Universidad de Granada; España
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Fil: Fernández Gil, Beatriz. Universidad de Granada; España
dc.description.fil
Fil: Guerra Librero, Ana. Universidad de Granada; España
dc.description.fil
Fil: García López, Sergio. Universidad de Granada; España
dc.description.fil
Fil: Shen, Ying. Universidad de Granada; España
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Fil: Florido, Javier. Universidad de Granada; España
dc.journal.title
Journal of Integrative Oncology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4172/2329-6771.S1-006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/melatonininduced-oncostasis-mechanisms-and-clinical-relevance-2329-6771-S1-006.php?aid=68975
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