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dc.contributor.author
Rosasco, María Ana  
dc.contributor.author
Segall, Adriana Ines  
dc.date.available
2018-03-19T21:34:40Z  
dc.date.issued
2015-12  
dc.identifier.citation
Rosasco, María Ana; Segall, Adriana Ines; Determination of the chemical stability of various formulations of tobramycin eye-drops by HPLC method and data analysis by R-GUI stability software; Open Science Publishers; Journal of Applied Pharmaceutical Science; 5; 12; 12-2015; 8-13  
dc.identifier.issn
2231-3354  
dc.identifier.uri
http://hdl.handle.net/11336/39310  
dc.description.abstract
Tobramycin, is a water soluble aminoglycoside antibiotic produced by the fungus Streptomyces tenebrarius and used in a variety of pharmaceutical applications including ophthalmic solutions, suspensions and ointments; inhalation solutions and intravenous administration. There are commercially available eye drops formulations in the Argentinian market that have different conservation conditions. We formulated six eye drops solutions, studied their stability at 2-8°C, 25°C, and 40°C, 75% RH and quantified using USP method. Only half of the formulations studied were found to be stable for two years at ambient temperature which is their expected expiry date and only one for three years in the same condition. One system was unstable in the three conservation conditions studied, including appearance and pH.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Open Science Publishers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Eyes-Drops  
dc.subject
Formulations  
dc.subject
Software Generated Shelf Life  
dc.subject
Stability  
dc.subject
Tobramycin  
dc.subject.classification
Farmacología y Farmacia  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Determination of the chemical stability of various formulations of tobramycin eye-drops by HPLC method and data analysis by R-GUI stability software  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-19T17:26:36Z  
dc.journal.volume
5  
dc.journal.number
12  
dc.journal.pagination
8-13  
dc.journal.pais
India  
dc.journal.ciudad
Bangalore  
dc.description.fil
Fil: Rosasco, María Ana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina  
dc.description.fil
Fil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Journal of Applied Pharmaceutical Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7324/JAPS.2015.501202  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.japsonline.com/abstract.php?article_id=1712