Mostrar el registro sencillo del ítem
dc.contributor.author
Lodillinsky, Catalina
dc.contributor.author
Podsypanina, Katrina
dc.contributor.author
Chavrier, Philippe
dc.date.available
2018-03-19T21:10:03Z
dc.date.issued
2016
dc.identifier.citation
Lodillinsky, Catalina; Podsypanina, Katrina; Chavrier, Philippe; Social networking in tumor cell communities is associated with increased aggressiveness; Taylor & Francis; IntraVital; 5; 1; 2016; 1-4; e1112476
dc.identifier.issn
2165-9087
dc.identifier.uri
http://hdl.handle.net/11336/39300
dc.description.abstract
Extracellular vesicles (EVs) are lipid-bilayer-enclosed vesicles that contain proteins, lipids and nucleic acids. EVs produced by cells from healthy tissues circulate in the blood and body fluids, and can be taken up by unrelated cells. As they have the capacity to transfer cargo proteins, lipids and nucleic acids (mostly mRNAs and miRNAs) between different cells in the body, EVs are emerging as mediators of intercellular communication that could modulate cell behavior, tissue homeostasis and regulation of physiological functions. EV-mediated cell-cell communications are also proposed to play a role in disease, for example, cancer, where they could contribute to transfer of traits required for tumor progression and metastasis. However, direct evidence for EV-mediated mRNA transfer to individual cells and for its biological consequences in vivo has been missing until recently. Recent studies have reported elegant experiments using genetic tracing with the Cre recombinase system and intravital imaging that visualize and quantify functional transfer of mRNA mediated by EVs in the context of cancer and metastasis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Extracellular Vesicles
dc.subject
Cell-Cell Comunication
dc.subject
Metastasis
dc.subject
Intravital Microscopy
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Social networking in tumor cell communities is associated with increased aggressiveness
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-19T17:27:24Z
dc.journal.volume
5
dc.journal.number
1
dc.journal.pagination
1-4; e1112476
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Lodillinsky, Catalina. Institute Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Podsypanina, Katrina. Institute Curie; Francia
dc.description.fil
Fil: Chavrier, Philippe. Institute Curie; Francia
dc.journal.title
IntraVital
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/21659087.2015.1112476
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/21659087.2015.1112476
Archivos asociados