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dc.contributor.author
Baldut, Mariela
dc.contributor.author
Bonafede, Silvina
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Petrone, Luciana
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Simionato, Laura Daniela
dc.contributor.author
Segall, Adriana Ines
dc.date.available
2018-03-19T21:08:36Z
dc.date.issued
2015-01
dc.identifier.citation
Baldut, Mariela; Bonafede, Silvina; Petrone, Luciana; Simionato, Laura Daniela; Segall, Adriana Ines; Development and Validation of a Complexometric Titration Method for the Determination of Rosuvastatin Calcium in Raw Material; ScienceDomain; Advances in Research; 5; 5; 1-2015; 1-8
dc.identifier.issn
2348-0394
dc.identifier.uri
http://hdl.handle.net/11336/39291
dc.description.abstract
Aims: An easy, sensitive and inexpensive volumetric method for the determination of rosuvastatin calcium in raw material has been developed. Methodology: The titrimetric method is based on the reaction of calcium with a solution of Disodium ethylene diaminotetraacetate (EDTA) - Magnesium 0.01 M. Hydroxynaphtol blue was used as indicator. It changes from pink to blue at pH = 10 at the end point of the titration. The method was validated for linearity, precision and accuracy, following the suggestions of the International Conference on Harmonization (ICH). Results: The linearity of the volumetric method was determined by analysis of six replicates at 80%, 100% and 120% and three replicates at 90% and 110% of analyte concentration. The calibration curve was linear, with r = 0.9998. Assay method precision was evaluated by carrying out six independent assays of bulk drug and the intermediate precision was also verified using different analyst and different day in the same laboratory. Accuracy (mean recovery 99.0%) and precision were found to be satisfactory. Conclusion: The proposed method can be used for quality control assay of rosuvastatin calcium in bulk drug.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
ScienceDomain
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Rosuvastatin Calcium
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Titrimetric
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Assay
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Complexometric Titration
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Development and Validation of a Complexometric Titration Method for the Determination of Rosuvastatin Calcium in Raw Material
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-19T17:26:34Z
dc.journal.volume
5
dc.journal.number
5
dc.journal.pagination
1-8
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Baldut, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
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Fil: Bonafede, Silvina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
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Fil: Petrone, Luciana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Simionato, Laura Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Advances in Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedomain.org/abstract/11174
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.9734/AIR/2015/19843
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