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dc.contributor.author
Ambrosioni, Juan
dc.contributor.author
Sued, Omar Gustavo
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dc.contributor.author
Nicolas, David
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Parera, Marta
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López Diéguez, María
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Romero, Anabel
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Agüero, Fernando
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Marcos, María Ángeles
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Manzardo, Christian
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Zamora, Laura
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Gómez Carrillo, Manuel
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Gatell, José María
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Pumarola, Tomás
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Miró, José María
dc.date.available
2018-03-19T17:26:54Z
dc.date.issued
2015-06
dc.identifier.citation
Ambrosioni, Juan; Sued, Omar Gustavo; Nicolas, David; Parera, Marta; López Diéguez, María; et al.; Trends in transmission of drug resistance and prevalence of Non-B subtypes in patients with acute or recent HIV-1 infection in Barcelona in the last 16 years (1997-2012); Public Library of Science; Plos One; 10; 6; 6-2015; 1-14; e0125837
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/39234
dc.description.abstract
Objectives: To evaluate the prevalence of transmitted drug resistance (TDR) and non-B subtypes in patients with acute/recent HIV-1 infection in Barcelona during the period 1997-2012. Methods: Patients from the "Hospital Clínic Primary HIV-1 Infection Cohort" with a genotyping test performed within 180 days of infection were included. The 2009 WHO List of Mutations for Surveillance of Transmitted HIV-1 Drug Resistance was used for estimating the prevalence of TDR and phylogenetic analysis for subtype determination. Results: 189 patients with acute/recent HIV-1 infection were analyzed in 4 time periods (1997-2000, n=28; 2001-4, n=42; 2005-8, n=55 and 2009-12, n=64). The proportion of patients with acute/recent HIV-1 infection with respect to the total of newly HIV-diagnosed patients in our center increased over the time and was 2.18%, 3.82%, 4.15% and 4.55% for the 4 periods, respectively (p=0.005). The global prevalence of TDR was 9%, or 17.9%, 9.5%, 3.6% and 9.4% by study period (p=0.2). The increase in the last period was driven by protease-inhibitor and nucleoside-reverse-transcriptase-inhibitor resistance mutations while non-nucleoside-reverse-transcriptase inhibitor TDR and TDR of more than one family decreased. The overall prevalence of non-B subtypes was 11.1%, or 0%, 4.8%, 9.1% and 20.3 by study period (p=0.01). B/F recombinants, B/G recombinants and subtype F emerged in the last period. We also noticed an increase in the number of immigrant patients (p=0.052). The proportion of men-who-have-sex-with-men (MSM) among patients with acute/recent HIV-1 infection increased over the time (p=0.04). Conclusions: The overall prevalence of TDR in patients with acute/recent HIV-1 infection in Barcelona was 9%, and it has stayed relatively stable in recent years. Non-B subtypes and immigrants proportions progressively increased.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hiv
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Aids
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Drug Resistance
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Subtypes
dc.subject.classification
Salud Ocupacional
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dc.subject.classification
Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Trends in transmission of drug resistance and prevalence of Non-B subtypes in patients with acute or recent HIV-1 infection in Barcelona in the last 16 years (1997-2012)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-13T13:55:00Z
dc.journal.volume
10
dc.journal.number
6
dc.journal.pagination
1-14; e0125837
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Ambrosioni, Juan. Universidad de Barcelona; España
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Fil: Sued, Omar Gustavo. Fundación Huésped; Argentina
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Fil: Nicolas, David. Universidad de Barcelona; España
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Fil: Parera, Marta. Universidad de Barcelona; España
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Fil: López Diéguez, María. Universidad de Barcelona; España
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Fil: Romero, Anabel. Agència de Qualitat i Avaluació Sanitàries de Catalunya; España
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Fil: Agüero, Fernando. Universidad de Barcelona; España
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Fil: Marcos, María Ángeles. Universidad de Barcelona; España
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Fil: Manzardo, Christian. Universidad de Barcelona; España
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Fil: Zamora, Laura. Universidad de Barcelona; España
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Fil: Gómez Carrillo, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
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Fil: Gatell, José María. Universidad de Barcelona; España
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Fil: Pumarola, Tomás. Universidad de Barcelona; España
dc.description.fil
Fil: Miró, José María. Universidad de Barcelona; España
dc.journal.title
Plos One
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0125837
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125837
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