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dc.contributor.author
García García, Maria de Lourdes
dc.contributor.author
Valdespino Gómez, Jose Luis
dc.contributor.author
García Sancho, Cecilia
dc.contributor.author
Mayar Maya, Maria Eugenia
dc.contributor.author
Palacios Martínez, Manuel
dc.contributor.author
Balandrano Campos, Susana
dc.contributor.author
Escobar Gutiérrez, Alejandro
dc.contributor.author
Peruga, Armando
dc.contributor.author
Weissenbacher, Mercedes Crecencia
dc.contributor.author
Daniels, Elaine
dc.date.available
2018-03-19T17:26:19Z
dc.date.issued
2000-04
dc.identifier.citation
García García, Maria de Lourdes; Valdespino Gómez, Jose Luis; García Sancho, Cecilia; Mayar Maya, Maria Eugenia; Palacios Martínez, Manuel; et al.; Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel; Oxford University Press; International Journal of Epidemiology; 29; 2; 4-2000; 369-375
dc.identifier.issn
0300-5771
dc.identifier.uri
http://hdl.handle.net/11336/39231
dc.description.abstract
Background. This study aimed to evaluate purified protein derivative (PPD) reactivity and its interrelationship with anergy panel and CD4+ lymphocytes in HIV-infected subjects as compared to PPD reactivity in HIV-uninfected individuals in a tuberculosis endemic and high Bacillus Calmette-Guerin (BCG) coverage environment. Methods. Clients of four Mexico City HIV detection centres were screened for HIV-1 anti-bodies (ELISA or haemagglutination, Western Blot); reactivity to PPD (Mantoux PPD, 5TU RT-23), Candida (1:1000, 0.1 ml), and tetanus toxoid (10Lf, 0.1 ml); and CD4+ T cells. Active tuberculosis was excluded. Informed consent was obtained. Results. From 5130 clients 1168 subjects were enrolled; of these 801 (68.6%) were HIV positive. Reactivity to PPD among HIV-positive subjects was found in 174 (22%), 261 (32.6%), and 296 (37%), at PPD cutoff levels of ≥10 mm, ≥5 mm, and ≥2 mm as compared to 224 (61%) of 367 HIV-negative individuals' reactors to PPD (≥10 mm) (P<0.001). After exclusion of anergic individuals using two cutoff levels for cutaneous allergens (≤2 mm and ≤5 mm), PPD reactivity between HIV-infected and uninfected individuals continued to be significantly different. Only HIV-infected individuals with CD4+ T cells ≥500 cells/mm3 had similar reactivity to PPD as HIV-uninfected individuals. Variables associated with PPD reactivity were CD4+ T cell counts, BCG scar, HIV infection and age. Conclusions. PPD reactivity was useful to diagnose tuberculosis infection only among HIV-infected individuals with CD4+ counts ≥500 cells/mm3. Among individuals with lower counts, lowering cutoff levels or using anergy panel did not permit comparable reactivity as that observed among HIV-uninfected individuals.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Anergy
dc.subject
Bcg Vaccine
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Cd4 Lymphocytes
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Delayed-Type Hypersensitivity
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Hiv
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Tuberculin Test
dc.subject.classification
Salud Ocupacional
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Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-16T15:14:52Z
dc.journal.volume
29
dc.journal.number
2
dc.journal.pagination
369-375
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: García García, Maria de Lourdes. Instituto de Salud Pública; México
dc.description.fil
Fil: Valdespino Gómez, Jose Luis. Instituto de Salud Pública; México
dc.description.fil
Fil: García Sancho, Cecilia. Instituto de Salud Pública; México
dc.description.fil
Fil: Mayar Maya, Maria Eugenia. Instituto de Salud Pública; México
dc.description.fil
Fil: Palacios Martínez, Manuel. Instituto de Salud Pública; México
dc.description.fil
Fil: Balandrano Campos, Susana. Instituto Nacional de Diagnóstico y Referencia Epidemiológicos; México
dc.description.fil
Fil: Escobar Gutiérrez, Alejandro. Instituto Nacional de Diagnóstico y Referencia Epidemiológicos; México
dc.description.fil
Fil: Peruga, Armando. PanAmerican Health Organization; Estados Unidos
dc.description.fil
Fil: Weissenbacher, Mercedes Crecencia. PanAmerican Health Organization; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Daniels, Elaine. National Institutes of Health; Estados Unidos
dc.journal.title
International Journal of Epidemiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/ije/29.2.369
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ije/article/29/2/369/758148
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