Mostrar el registro sencillo del ítem
dc.contributor.author
Colombo, Lucas Luis
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Stazzone, Anthony
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Chen, Guan Jie
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Lopez, Maria C.
dc.contributor.author
Watson, Ronald R.
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2018-03-19T17:24:38Z
dc.date.issued
2000-03
dc.identifier.citation
Colombo, Lucas Luis; Stazzone, Anthony; Chen, Guan Jie; Lopez, Maria C.; Watson, Ronald R.; Behavioral and immune changes in v-HA-ras transgenic mice; Taylor ; Immunopharmacology And Immunotoxicology; 22; 2; 3-2000; 339-356
dc.identifier.issn
0892-3973
dc.identifier.uri
http://hdl.handle.net/11336/39223
dc.description.abstract
Transgenic mice (Oncomice) with an activated v-Ha-ras oncogene under the control of the mouse mammary tumor virus promoter develop mammary tumors. We wondered if the expression of the v-Ha-ras oncogene product would induce changes in mice behavioral activity, that could be associated with alterations in their immune system. Behavior was evaluated in an open field study considering line crossings and rears. Oncomice consistently showed less activity than FVB mice. Lieber-DeCarli diet decreased both types of activity in both strains. Cocaine treatment increased line crossings in both strains. Oncomice spleen and thymus cell supernatants contained higher levels of IL-2. Oncomice serum had higher levels of IL-1α. Our results suggest a direct association between higher levels of IL-1α and lower open field activity. Therefore, we can infer that the increased level of IL-1α found in Oncomice, could have a key role in oncogene induced immune and behavioral changes, and could be a requirement to facilitate its transforming activity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Behavior
dc.subject
Immunity
dc.subject
Ha-Ras Transgenic Mice
dc.subject
Oncogene
dc.subject.classification
Inmunología
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Básica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Behavioral and immune changes in v-HA-ras transgenic mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-16T15:13:01Z
dc.journal.volume
22
dc.journal.number
2
dc.journal.pagination
339-356
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.description.fil
Fil: Colombo, Lucas Luis. University of Arizona; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Stazzone, Anthony. University of Arizona; Estados Unidos
dc.description.fil
Fil: Chen, Guan Jie. University of Arizona; Estados Unidos
dc.description.fil
Fil: Lopez, Maria C.. University of Arizona; Estados Unidos
dc.description.fil
Fil: Watson, Ronald R.. University of Arizona; Estados Unidos
dc.journal.title
Immunopharmacology And Immunotoxicology
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/08923970009016424
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/08923970009016424
Archivos asociados