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dc.contributor.author
Reis, M. F.
dc.contributor.author
Cobellis, L.
dc.contributor.author
Luisi, S.
dc.contributor.author
Driul, L.
dc.contributor.author
Florio, P.
dc.contributor.author
Faletti, Alicia Graciela
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dc.contributor.author
Petraglia, F.
dc.date.available
2018-03-19T15:45:36Z
dc.date.issued
2000-12
dc.identifier.citation
Reis, M. F.; Cobellis, L.; Luisi, S.; Driul, L.; Florio, P.; et al.; Paracrine/autocrine control of female reproduction; Informa Healthcare; Gynecological Endocrinology; 14; 6; 12-2000; 464-475
dc.identifier.issn
0951-3590
dc.identifier.uri
http://hdl.handle.net/11336/39198
dc.description.abstract
Neuropeptides, growth factors and cytokines are expressed in reproductive organs and tissues, where they interact with afferent endocrine messages to modulate cell proliferation and differentiation, local hormone secretion and vascular function. These events regulate complex processes such as gonadotropin pulsatility, ovulation, implantation and parturition. During reproductive life, a number of neuropeptides produced within the hypothalamus play a modulatory role in the control of gonadotropin-releasing hormone (GnRH) release, hence characterizing a hypothalamic paracrine system. The pituitary gland is a source and target of inhibin-related proteins, and these typical 'gonadal' products, once secreted by the pituitary cells, acquire the function of paracrine modulators of follide-stimulating hormone (FSH) secretion. In the ovary, the effect of gonadotropins is locally modulated by growth factors acting in an autocrine/paracrine manner, although their precise role in folliculogenesis remains uncertain. Numerous local factors are involved in the control of endometrial growth, differentiation, receptivity and menstruation. Alterations in the paracrine endometrial system may underlie pathological processes such as infertility or endometrial neoplasia. The human placenta and its related membranes produce cytokines, hormones and growth factors that participate in the control of gestational development as well as in the maternal-fetal adaptation to gestational diseases. There is increasing evidence that paracrine signaling plays a fundamental role in all spheres of female reproductive function, and future research will concentrate on clarifying which of these local mechanisms play a decisive role in both physiology and disease, thus giving rise to new therapeutic strategies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Informa Healthcare
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cytokines
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Growth Factors
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Neuropeptides
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Ovary
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Paracrine
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Pituitary
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Placenta
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Uterus
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Paracrine/autocrine control of female reproduction
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-16T15:13:26Z
dc.journal.volume
14
dc.journal.number
6
dc.journal.pagination
464-475
dc.journal.pais
Reino Unido
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dc.journal.ciudad
London
dc.description.fil
Fil: Reis, M. F.. Università degli Studi di Siena; Italia
dc.description.fil
Fil: Cobellis, L.. Università degli Studi di Siena; Italia
dc.description.fil
Fil: Luisi, S.. Università degli Studi di Siena; Italia
dc.description.fil
Fil: Driul, L.. Università degli Studi di Siena; Italia
dc.description.fil
Fil: Florio, P.. Università degli Studi di Siena; Italia
dc.description.fil
Fil: Faletti, Alicia Graciela. Università degli Studi di Siena; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Petraglia, F.. Università degli Studi di Siena; Italia
dc.journal.title
Gynecological Endocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/09513590009167720
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/09513590009167720
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