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dc.contributor.author
López Ordieres, María Graciela
dc.contributor.author
Rodriguez, Georgina Emma
dc.date.available
2018-03-16T23:51:08Z
dc.date.issued
2000-03
dc.identifier.citation
López Ordieres, María Graciela; Rodriguez, Georgina Emma; Neurotensin inhibits neuronal Na+, K+-ATPase activity through high affinity peptide receptor; Elsevier Science Inc; Peptides; 21; 4; 3-2000; 571-576
dc.identifier.issn
0196-9781
dc.identifier.uri
http://hdl.handle.net/11336/39162
dc.description.abstract
Neurotensin is a peptide present in mammalian CNS and peripheral tissues, which may play a major role in neurotransmission or neuromodulation, subserving diverse physiological functions. We studied the effect of added neurotensin on ATPase activities in synaptosomal membranes isolated from rat cerebral cortex. Neurotensin at 3 x 10-8-3 x 10-6 M concentration decreased 20-44% Na+, K+-ATPase activity but failed to modify Mg2+-ATPase activity; lower neurotensin concentrations (3 x 10-14-3 x 10-10 M) had no effect on enzyme activities. This inhibitory effect was abolished by neurotensin heating, by enzyme preincubation with neurotensin during periods exceeding 10 min, or by adding 1 x 10-6 M SR 48692, a high affinity neurotensin receptor antagonist. Levocabastine, which blocks low affinity neurotensin receptor, failed to alter enzyme inhibition by the peptide. It is suggested that the sodium pump may be a target for neurotensin effects at neuronal level involving the participation of high affinity neurotensin receptor. © 2000 Elsevier Science Inc.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Atpases
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K+-Atpase
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Na+
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Neurotensin Effect
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Neurotensin Receptor
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Synaptosomal Membrane Enzymes
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Neurotensin inhibits neuronal Na+, K+-ATPase activity through high affinity peptide receptor
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-16T15:16:18Z
dc.journal.volume
21
dc.journal.number
4
dc.journal.pagination
571-576
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: López Ordieres, María Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina
dc.description.fil
Fil: Rodriguez, Georgina Emma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina
dc.journal.title
Peptides
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://europepmc.org/abstract/med/10822114
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/S0196-9781(00)00183-2
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