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dc.contributor.author
Acosta, Gabriela Beatriz
dc.contributor.author
Boccia, Mariano Martín
dc.contributor.author
Baratti, Carlos Maria
dc.date.available
2018-03-16T22:38:06Z
dc.date.issued
2000-02
dc.identifier.citation
Acosta, Gabriela Beatriz; Boccia, Mariano Martín; Baratti, Carlos Maria; Gabapentin, an antiepileptic drug, improves memory storage in mice; Elsevier Ireland; Neuroscience Letters; 279; 3; 2-2000; 173-176
dc.identifier.issn
0304-3940
dc.identifier.uri
http://hdl.handle.net/11336/39145
dc.description.abstract
Male CF-1 mice were tested 48 h after training in a one-trial step- through inhibitory avoidance task. Immediately post-training i.p. injections of the antiepileptic drug gabapentin (1-aminomethyl cyclohexaneacetic acid) (GBP; 5, 10, 50, and 100 mg/kg) induced a dose-dependent enhancement of retention performance. Gabapentin did not affect response latencies in mice not given the footshock on the training trial, indicating that the actions of GBP on retention were not due to non-specific proactive effects on response latencies. The effects of GBP (10 mg/kg) were time-dependent, and the administration of GBP (10 mg/kg) 30 min before training also enhanced retention performance. However, the administration of GBP (10 mg/kg) 30 min prior to the retention test did not modify retention latencies of mice that had received either saline or GBP (10 mg/kg) immediately after training. Altogether, the results suggest that GBP influences retention by modulating time-dependent processes involved in memory storage, although the mechanism(s) of this action remain to be established. (C) 2000 Elsevier Science Ireland Ltd.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
(1-Aminomethyl) Cyclohexane Acetic Acid
dc.subject
Anticonvulsants
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Antiepileptics
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Gabapentin
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Inhibitory Avoidance
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Memory
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Memory Storage
dc.subject
Retention
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Gabapentin, an antiepileptic drug, improves memory storage in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-16T15:12:30Z
dc.journal.volume
279
dc.journal.number
3
dc.journal.pagination
173-176
dc.journal.pais
Irlanda
dc.journal.ciudad
Shannon
dc.description.fil
Fil: Acosta, Gabriela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Boccia, Mariano Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Baratti, Carlos Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina
dc.journal.title
Neuroscience Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/S0304-3940(00)00760-6
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304394000007606


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