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dc.contributor.author
Picconi, María A.
dc.contributor.author
Eijan, Ana Maria
dc.contributor.author
Distéfano, Angélica L.
dc.contributor.author
Pueyo, Silvia
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Alonio, Lidia Virginia
dc.contributor.author
Gorostidi, Susana
dc.contributor.author
Teyssié, Angélica R.
dc.contributor.author
Casabone, Bernardo Adalberto
dc.date.available
2018-03-16T21:13:40Z
dc.date.issued
2000-05
dc.identifier.citation
Picconi, María A.; Eijan, Ana Maria; Distéfano, Angélica L.; Pueyo, Silvia; Alonio, Lidia Virginia; et al.; Human papillomavirus (HPV) DNA in penile carcinomas in Argentina: Analysis of primary tumors and lymph nodes; Wiley-liss, Div John Wiley & Sons Inc; Journal of Medical Virology; 61; 1; 5-2000; 65-69
dc.identifier.issn
0146-6615
dc.identifier.uri
http://hdl.handle.net/11336/39143
dc.description.abstract
Among sexually transmitted diseases, infection by human papillomavirus (HPV) has become one of the most important. On the other hand, though epidemiological data show that some HPV types are closely associated with cervical cancer, few reports have been found with reference to penile carcinoma because of its rare occurrence. The aim of this study was to investigate the relationship between HPV infection and penile cancer in Argentina. A retrospective study was carried out on 38 white men with penile squamous-cell carcinoma. Sixty-five archival fixed biopsies taken from 34 primary penile tumors, 25 nodal metastases, 1 skin “satellite” metastasis and 5 histologically normal lymph nodes were used as specimens. HPV detection and typing were carried out by the polymerase chain reaction (PCR) using generic primers, combined with single-stranded conformational polymorphism (SSCP) analysis. HPV DNA was found in 71% patients, corresponding 81% of them to “high risk” types, with predominance of HPV 18. Both primary tumors and metastases showed concordance of HPV occurrence and type in both lesions. In 3 patients, HPV 16 was detected not only in primary tumors and metastases, but also in histologically normal lymph nodes. Our data indicate that most penile carcinomas in Argentine patients are etiologically related to HPV, especially to “high risk” genital types. The agreement in HPV detection between primary tumors and metastases suggests a potential viral role in tumor progression. HPV detection in otherwise histologically normal lymph nodes might be useful as early marker of a metastatic process.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hpv
dc.subject
Penile Carcinomas
dc.subject.classification
Salud Ocupacional
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Human papillomavirus (HPV) DNA in penile carcinomas in Argentina: Analysis of primary tumors and lymph nodes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-16T15:13:24Z
dc.journal.volume
61
dc.journal.number
1
dc.journal.pagination
65-69
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Picconi, María A.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C.G. Malbrán”; Argentina
dc.description.fil
Fil: Eijan, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Distéfano, Angélica L.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C.G. Malbrán”; Argentina
dc.description.fil
Fil: Pueyo, Silvia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Materno Infantil de San Isidro. Servicio de Dermatología; Argentina
dc.description.fil
Fil: Alonio, Lidia Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C.G. Malbrán”; Argentina
dc.description.fil
Fil: Gorostidi, Susana. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Teyssié, Angélica R.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C.G. Malbrán”; Argentina
dc.description.fil
Fil: Casabone, Bernardo Adalberto. Universidad de Buenos Aires; Argentina
dc.journal.title
Journal of Medical Virology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/(SICI)1096-9071(200005)61:1<65::AID-JMV10>3.0.CO;2-Z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9071(200005)61:1%3C65::AID-JMV10%3E3.0.CO;2-Z/full


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