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dc.contributor.author
Hazen, Samuel P.
dc.contributor.author
Borevitz, Justin O.
dc.contributor.author
Harmon, Frank G.
dc.contributor.author
Pruneda Paz, Jose Luis Pablo
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dc.contributor.author
Schultz, Thomas F.
dc.contributor.author
Yanovsky, Marcelo Javier
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dc.contributor.author
Liljegren, Sarah J.
dc.contributor.author
Ecker, Joseph R.
dc.contributor.author
Kay, Steve A.
dc.date.available
2018-03-16T15:54:56Z
dc.date.issued
2005-12
dc.identifier.citation
Hazen, Samuel P.; Borevitz, Justin O.; Harmon, Frank G.; Pruneda Paz, Jose Luis Pablo; Schultz, Thomas F.; et al.; Rapid array mapping of circadian clock and developmental mutations in Arabidopsis; American Society of Plant Biologist; Plant Physiology; 138; 2; 12-2005; 990-997
dc.identifier.issn
0032-0889
dc.identifier.uri
http://hdl.handle.net/11336/39079
dc.description.abstract
Classical forward genetics, the identification of genes responsible for mutant phenotypes, remains an important part of functional characterization of the genome. With the advent of extensive genome sequence, phenotyping and genotyping remain the critical limiting variables in the process of map-based cloning. Here, we reduce the genotyping problem by hybridizing labeled genomic DNA to the Affymetrix Arabidopsis (Arabidopsis thaliana) ATH1 GeneChip. Genotyping was carried out on the scale of detecting greater than 8,000 single feature polymorphisms from over 200,000 loci in a single assay. By combining this technique with bulk segregant analysis, several high heritability development and circadian clock traits were mapped. The mapping accuracy using bulk pools of 26 to 100 F2 individuals ranged from 0.22 to 1.96 Mb of the mutations revealing mutant alleles of EARLY FLOWERING 3, EARLY FLOWERING 4, TIMING OF CAB EXPRESSION 1, and ASYMMETRIC LEAVES 1. While direct detection of small mutations, such as an ethyl-methane sulfonate derived single base substitutions, is limited by array coverage and sensitivity, large deletions such as those that can be caused by fast neutrons are easily detected. We demonstrate this by resolving two deletions, the 77-kb flavin-binding, kelch repeat, f-box 1 and the 7-kb cryptochrome2-1 deletions, via direct hybridization of mutant DNA to ATH1 expression arrays.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Plant Biologist
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Plant Biology
dc.subject
Arabidopsis
dc.subject
Circadian Clock
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Rapid array mapping of circadian clock and developmental mutations in Arabidopsis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-15T15:22:31Z
dc.identifier.eissn
1532-2548
dc.journal.volume
138
dc.journal.number
2
dc.journal.pagination
990-997
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Rockville
dc.description.fil
Fil: Hazen, Samuel P.. The Scripps Research Institute; Estados Unidos
dc.description.fil
Fil: Borevitz, Justin O.. University of Chicago; Estados Unidos. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Harmon, Frank G.. The Scripps Research Institute; Estados Unidos
dc.description.fil
Fil: Pruneda Paz, Jose Luis Pablo. The Scripps Research Institute; Estados Unidos
dc.description.fil
Fil: Schultz, Thomas F.. The Scripps Research Institute; Estados Unidos
dc.description.fil
Fil: Yanovsky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura; Argentina
dc.description.fil
Fil: Liljegren, Sarah J.. The Scripps Research Institute; Estados Unidos
dc.description.fil
Fil: Ecker, Joseph R.. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Kay, Steve A.. The Scripps Research Institute; Estados Unidos
dc.journal.title
Plant Physiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.plantphysiol.org/content/138/2/990.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1104/pp.105.061408
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