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dc.contributor.author
Carrascosa, Patricia
dc.contributor.author
Leipsic, Jonathon A.
dc.contributor.author
Capunay, Carlos
dc.contributor.author
Deviggiano, Alejandro
dc.contributor.author
Vallejos, Javier
dc.contributor.author
Goldsmit, Alejandro
dc.contributor.author
Rodriguez Granillo, Gaston Alfredo
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dc.date.available
2018-03-15T20:31:39Z
dc.date.issued
2015-10
dc.identifier.citation
Carrascosa, Patricia; Leipsic, Jonathon A.; Capunay, Carlos; Deviggiano, Alejandro; Vallejos, Javier; et al.; Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography; Elsevier Ireland; European Journal Of Radiology; 84; 10; 10-2015; 1915-1920
dc.identifier.issn
0720-048X
dc.identifier.uri
http://hdl.handle.net/11336/39025
dc.description.abstract
Purpose: To compare image interpretability and diagnostic performance of dual-energy CT coronary angiography (DE-CTCA) performed with 50% iodine load reduction versus single energy acquisitions (SE-CTCA) with full iodine load. Materials and methods: The present prospective study involved patients with suspected coronary artery disease (CAD) clinically referred for CTCA. DE-CTCA with 50% iodine volume load was performed first, and after heart rate returned to baseline SE-CTCA was performed using full iodine volume load. The primary endpoint was to compare image interpretability between groups. DE-CTCA was performed by rapid switching between low and high tube potentials (80–140 kV) from a single source, allowing the generation of monochromatic image reconstructions ranging from 40 to 140 keV. Image quality assessment was performed using a 5-point Likert scale. Results: Thirty-six patients constituted the study population. The mean heart rate before the CT scan (DE-CTCA 57.3 ± 10.7 bpm vs. SE-CTCA 58.5 ± 11.2 bpm, p = 0.29) and the mean effective radiation dose (3.5 ± 1.9 mSv vs. 3.8 ± 0.9 mSv, p = 0.48) did not differ between groups. Likert image quality scores were similar between groups (DE-CTCA 4.42 ± 0.98 vs. SE-CTCA 4.43 ± 0.84, p = 0.67). Signal-to-noise and contrast-to-noise ratios were significantly lower with DE-CTCA, driven by lower signal density levels at 60 keV compared to SE-CTCA. The sensitivity and specificity for the detection of stenosis >50% was indistinguishable between groups (DE-CTCA 84.4% (69.9–93.0%), 87.1% (81.6–91.2%); SE-CTCA 84.4% (69.9–93.0%), 87.1% (81.6–91.2%). Conclusions: In this pilot, prospective study, dual energy CTCA imaging with half iodine load achieved comparable interpretability than full iodine load with single energy CTCA.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Atherosclerosis
dc.subject
Contrast Material
dc.subject
Coronary Artery Disease
dc.subject
Imaging
dc.subject
Volume
dc.subject.classification
Medicina Critica y de Emergencia
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-14T17:03:58Z
dc.journal.volume
84
dc.journal.number
10
dc.journal.pagination
1915-1920
dc.journal.pais
Irlanda
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dc.description.fil
Fil: Carrascosa, Patricia. Diagnostico Maipu; Argentina
dc.description.fil
Fil: Leipsic, Jonathon A.. St. Paul's Hospital; Canadá
dc.description.fil
Fil: Capunay, Carlos. Diagnostico Maipu; Argentina
dc.description.fil
Fil: Deviggiano, Alejandro. Diagnostico Maipu; Argentina
dc.description.fil
Fil: Vallejos, Javier. Diagnostico Maipu; Argentina
dc.description.fil
Fil: Goldsmit, Alejandro. Sanatorio Güemes; Argentina
dc.description.fil
Fil: Rodriguez Granillo, Gaston Alfredo. Diagnostico Maipu; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
European Journal Of Radiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejrad.2015.06.019
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0720048X15300267
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