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dc.contributor.author
Cury, R. G.  
dc.contributor.author
Galhardoni, R.  
dc.contributor.author
Fonoff, E. T.  
dc.contributor.author
Pérez Lloret, Santiago  
dc.contributor.author
Santos Ghilardi, Maria Gabriela dos  
dc.contributor.author
Barbosa, E. R.  
dc.contributor.author
Teixeira, M. J.  
dc.contributor.author
Ciampi de Andrade, Daniel  
dc.date.available
2018-03-15T20:11:57Z  
dc.date.issued
2016-02  
dc.identifier.citation
Cury, R. G.; Galhardoni, R.; Fonoff, E. T.; Pérez Lloret, Santiago; Santos Ghilardi, Maria Gabriela dos; et al.; Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms; Elsevier; European Journal of Pain; 20; 2; 2-2016; 151-165  
dc.identifier.issn
1090-3801  
dc.identifier.uri
http://hdl.handle.net/11336/39009  
dc.description.abstract
Pain and sensory abnormalities are present in a large proportion of Parkinson disease (PD) patients and have a significant negative impact in quality of life. It remains undetermined whether pain occurs secondary to motor impairment and to which extent it can be relieved by improvement of motor symptoms. The aim of this review was to examine the current knowledge on the mechanisms behind sensory changes and pain in PD and to assess the modulatory effects of motor treatment on these sensory abnormalities. A comprehensive literature search was performed. We selected studies investigating sensory changes and pain in PD and the effects of levodopa administration and deep brain stimulation (DBS) on these symptoms. PD patients have altered sensory and pain thresholds in the off-medication state. Both levodopa and DBS improve motor symptoms (i.e.: bradykinesia, tremor) and change sensory abnormalities towards normal levels. However, there is no direct correlation between sensory/pain changes and motor improvement, suggesting that motor and non-motor symptoms do not necessarily share the same mechanisms. Whether dopamine and DBS have a real antinociceptive effect or simply a modulatory effect in pain perception remain uncertain. These data may provide useful insights into a mechanism-based approach to pain in PD, pointing out the role of the dopaminergic system in pain perception and the importance of the characterization of different pain syndromes related to PD before specific treatment can be instituted.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Enfermedad de Parkinson  
dc.subject
Dolor  
dc.subject
Estimación Cerebral Profunda  
dc.subject.classification
Medicina Critica y de Emergencia  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-14T17:04:32Z  
dc.journal.volume
20  
dc.journal.number
2  
dc.journal.pagination
151-165  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Cury, R. G.. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Galhardoni, R.. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Fonoff, E. T.. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina  
dc.description.fil
Fil: Santos Ghilardi, Maria Gabriela dos. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Barbosa, E. R.. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Teixeira, M. J.. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Ciampi de Andrade, Daniel. Universidade de Sao Paulo; Brasil  
dc.journal.title
European Journal of Pain  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ejp.745  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ejp.745/abstract