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Artículo

Beneficial effect of moderate exercise in kidney of rat after chronic consumption of cola drinks

Cao, Gabriel FernandoIcon ; Gonzalez, JulianIcon ; Muller, Maria Angelica; Ottaviano, Graciela MabelIcon ; Ambrosio, Giuseppe; Toblli, Jorge EduardoIcon ; Milei, JoseIcon
Fecha de publicación: 03/2016
Editorial: Public Library of Science
Revista: Plos One
ISSN: 1932-6203
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias de la Salud

Resumen

Aim: The purpose of this study was to investigate the effect of moderate intensity exercise on kidney in an animal model of high consumption of cola soft drinks. Methods: Forty-eight Wistar Kyoto rats (age: 16 weeks; weight: 350-400 g) were assigned to the following groups: WR (water runners) drank water and submitted to aerobic exercise; CR (cola runners) drank cola and submitted to aerobic exercise; WS (water sedentary) and CS (cola sedentary), not exercised groups. The aerobic exercise was performed for 5 days per week throughout the study (24 weeks) and the exercise intensity was gradually increased during the first 8 weeks until it reached 20 meters / minute for 30 minutes. Body weight, lipid profile, glycemia, plasma creatinine levels, atherogenic index of plasma (AIP) and systolic blood pressure (SBP) were determined. After 6 months all rats were sacrificed. A kidney histopathological score was obtained using a semiquantitative scale. Glomerular size and glomerulosclerosis were estimated by point-counting. The oxidative stress and proinflammatory status were explored by immunohistochemistry. A one way analysis of variance (ANOVA) with Tukey-Kramer post-hoc test or the Kruskal-Wallis test with Dunn's post-hoc test was used for statistics. A value of p < 0.05 was considered significant. Results: At 6 months, an increased consumption of cola soft drink was shown in CS and CR compared with water consumers (p<0.0001). Chronic cola consumption was associated with increased plasma triglycerides, AIP, heart rate, histopathological score, glomerulosclerosis, oxidative stress and pro-inflammatory status. On the other hand, moderate exercise prevented these findings. No difference was observed in the body weight, SBP, glycemia, cholesterol and plasma creatinine levels across experimental groups. Conclusions: This study warns about the consequences of chronic consumption of cola drinks on lipid metabolism, especially regarding renal health. Additionally, these findings emphasize the protective role of exercise training on renal damage.
Palabras clave: Cola Drinks , Metabolism , Renal Damage
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/38971
DOI: http://dx.doi.org/10.1371/journal.pone.0152461
URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152461
Colecciones
Articulos(ININCA)
Articulos de INST.DE INVEST.CARDIOLOGICAS (I)
Citación
Cao, Gabriel Fernando; Gonzalez, Julian; Muller, Maria Angelica; Ottaviano, Graciela Mabel; Ambrosio, Giuseppe; et al.; Beneficial effect of moderate exercise in kidney of rat after chronic consumption of cola drinks; Public Library of Science; Plos One; 11; 3; 3-2016; 1-16; e0152461
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