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dc.contributor.author
Pirola, Carlos José  
dc.contributor.author
Sookoian, Silvia Cristina  
dc.date.available
2018-03-15T18:19:38Z  
dc.date.issued
2016-04  
dc.identifier.citation
Pirola, Carlos José; Sookoian, Silvia Cristina; The modulation of liver methylome in liver diseases; Elsevier Science; Journal of Hepatology; 64; 4; 4-2016; 987-988  
dc.identifier.issn
0168-8278  
dc.identifier.uri
http://hdl.handle.net/11336/38962  
dc.description.abstract
The importance of 5-Hydroxymethylcytosine (5-hmC) in the biology of non-cancerous human liver diseases, particularly nonalcoholic fatty liver disease (NAFLD), was recently described for the first time by our group [2]. We observed that nonnuclear-5-hmC, which is probably located in mitochondria, is lower in NAFLD as compared with controls. Therefore, 5-hmC may be involved in the modulation of the mitochondrial DNA methylome and gene expression, in particular components of the oxidative phosphorylation-chain, a finding that could explain much of the changes that occur during NAFLD disease progression, including fibrogenesis  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.relation
Referido a https://doi.org/10.1016/j.jhep.2015.11.024  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Epigenetics  
dc.subject
Nafld  
dc.subject
Methylation  
dc.subject
Tet Proteins  
dc.subject.classification
Medicina Critica y de Emergencia  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
The modulation of liver methylome in liver diseases  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-14T17:12:58Z  
dc.journal.volume
64  
dc.journal.number
4  
dc.journal.pagination
987-988  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina  
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina  
dc.journal.title
Journal of Hepatology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jhep.2015.12.024  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168827816000167  

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