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Artículo

Genetic Variability of AdeRS Two-Component System Associated with Tigecycline Resistance in XDR-Acinetobacter baumannii Isolates

Montaña, Sabrina DaianaIcon ; Vilacoba, ElisabetIcon ; Traglia, German MatiasIcon ; Almuzara, Marisa; Pennini, M.; Fernández, A.; Sucari, A.; Centron, DanielaIcon ; Ramirez, Maria SoledadIcon
Fecha de publicación: 07/2015
Editorial: Springer
Revista: Current Microbiology
ISSN: 0343-8651
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

The emergence of tigecycline resistance has increased in the last years. Although tigecycline-resistant Acinetobacter baumannii isolates were described all over the world, few reports regarding the molecular basis of this resistance are available. It has been recognized that the overexpression of AdeABC efflux pump is related to the tigecycline-resistant phenotype. In 37 clinical A. baumannii isolates we first determined the tigecycline-resistant phenotype and then, within a selected group, we analyzed the sequence of the adeRS operon, which is involved in the expression of the AdeABC efflux pump. Nucleotide sequence analysis of adeR and adeS showed the presence of 5 and 16 alleles, respectively. These results expose a high genetic variability in both genes, the adeS gene being more susceptible to genetic variation. The presence of 2 AdeR and 2 AdeS new variants were reported. Two of the new AdeRS variants were present in the intermediate and the resistant tigecycline A. baumannii isolates, suggesting a putative role in the development of the observed phenotype. More studies need to be addressed to determine the role of the genetic variability observed in the adeRS operon.
Palabras clave: Acinetobacter Baumanni , Insertion Sequence , Antibiotic Resistance , Genetic
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/38956
DOI: http://dx.doi.org/10.1007/s00284-015-0829-3
URL: https://link.springer.com/article/10.1007%2Fs00284-015-0829-3
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Articulos(IMPAM)
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Citación
Montaña, Sabrina Daiana; Vilacoba, Elisabet; Traglia, German Matias; Almuzara, Marisa; Pennini, M.; et al.; Genetic Variability of AdeRS Two-Component System Associated with Tigecycline Resistance in XDR-Acinetobacter baumannii Isolates; Springer; Current Microbiology; 71; 1; 7-2015; 76-82
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