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Artículo

Hippocampal dynamics of synaptic NF-kappa B during inhibitory avoidance long-term memory consolidation in mice

Salles, AngelesIcon ; Boccia, Mariano MartínIcon ; Blake, Mariano GuillermoIcon ; Corbi, N.; Passananti, C.; Baratti, Carlos MariaIcon ; Romano, Arturo GabrielIcon ; Freudenthal, Ramiro A. M.Icon
Fecha de publicación: 04/2015
Editorial: Pergamon-Elsevier Science Ltd
Revista: Neuroscience
ISSN: 0306-4522
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

Since the discovery that long-term memory is dependent on protein synthesis, several transcription factors have been found to participate in the transcriptional activity needed for its consolidation. Among them, NF-kappa B is a constitutive transcription factor whose nuclear activity has proven to be necessary for the consolidation of inhibitory avoidance in mice. This transcription factor has a wide distribution in the nervous system, with a well-reported presence in dendrites and synaptic terminals. Here we report changes in synaptosomal NF-kappa B localization and activity, during long-term memory consolidation. Activity comparison of synaptosomal and nuclear NF-kappa B, indicates different dynamics for both localizations. In this study we identify two pools of synaptosomal NF-kappa B, one obtained with the synaptoplasm (free fraction) and the second bound to the synaptosomal membranes. During the early steps of consolidation the first pool is activated, as the membrane associated transcription factor fraction increases and concomitantly the free fraction decreases. These results suggest that the activation of synaptic NF-kappa B and its translocation to membranes are part of the consolidation of long-term memory in mice.
Palabras clave: I Kappa B Alpha , Memory Consolidation , Nf-Kappa B , Synapse
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/38914
DOI: http://dx.doi.org/10.1016/j.neuroscience.2015.01.063
URL: https://www.sciencedirect.com/science/article/pii/S0306452215001311
Colecciones
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Salles, Angeles; Boccia, Mariano Martín; Blake, Mariano Guillermo; Corbi, N.; Passananti, C.; et al.; Hippocampal dynamics of synaptic NF-kappa B during inhibitory avoidance long-term memory consolidation in mice; Pergamon-Elsevier Science Ltd; Neuroscience; 291; 4-2015; 70-80
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