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dc.contributor.author
Barrantes, Francisco Jose  
dc.contributor.author
Fantini, Jacques  
dc.date.available
2018-03-15T17:01:55Z  
dc.date.issued
2016-07  
dc.identifier.citation
Barrantes, Francisco Jose; Fantini, Jacques; From hopanoids to cholesterol: Molecular clocks of pentameric ligand-gated ion channels; Pergamon-Elsevier Science Ltd; Progress in Lipid Research; 63; 7-2016; 1-13  
dc.identifier.issn
0163-7827  
dc.identifier.uri
http://hdl.handle.net/11336/38905  
dc.description.abstract
Pentameric ligand-gated ion channels (pLGIC) and their lipid microenvironments appear to have acquired mutually adaptive traits along evolution: 1) the three-ring architecture of their transmembrane (TM) region; 2) the ability of the outermost TM ring to convey lipid signals to the middle ring, which passes them on to the central pore ring, and 3) consensus motifs for sterol recognition in all pLGIC. Hopanoids are triterpenoid fossil lipids that constitute invaluable biomarkers for tracing evolution at the molecular scale. The cyanobacterium Gloeobacter violaceus is the oldest known living organism in which the X-ray structure of its pLGIC, GLIC, reveals the presence of the above attributes and, as discussed in this review, the ability to bind hopanoids. ELIC, the pLGIC from the bacillum Erwinia chrysanthemi is the only other known case. Both prokaryotes lack cholesterol but their pLGICs exhibit the same sterol motifs as mammalian pLGIC. This remarkable conservation suggests that the association of sterols and hopanoid surrogate molecules arose from the early need in prokaryotes to stabilize pLGIC TM regions by means of relatively rigid lipid molecules. The conservation of these phenotypic traits along such a long phylogenetic span leads us to suggest the possible co-evolution of these sterols with pLGIC.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Ion Channell Evolution  
dc.subject
Evolution  
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Cholesterol  
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Prokaryotes And Eukaryots  
dc.subject
Hopanoids  
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Pentameric Ligand-Gated Ion Channels  
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Steroids  
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Gloeobacter  
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Erwinia  
dc.subject.classification
Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
From hopanoids to cholesterol: Molecular clocks of pentameric ligand-gated ion channels  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-15T14:04:19Z  
dc.journal.volume
63  
dc.journal.pagination
1-13  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina  
dc.description.fil
Fil: Fantini, Jacques. Aix-Marseille Université; Francia  
dc.journal.title
Progress in Lipid Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.plipres.2016.03.003  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0163782715300308