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dc.contributor.author
Vilariño García, T.
dc.contributor.author
Pérez Pérez, A.
dc.contributor.author
Dietrich, Valeria
dc.contributor.author
Fernández Sánchez, M.
dc.contributor.author
Guadix, Dolores
dc.contributor.author
Dueñas, J. L.
dc.contributor.author
Varone, Cecilia Laura
dc.contributor.author
Damiano, Alicia Ermelinda
dc.contributor.author
Sánchez Margalet, V.
dc.date.available
2018-03-15T17:01:34Z
dc.date.issued
2016-08
dc.identifier.citation
Vilariño García, T.; Pérez Pérez, A.; Dietrich, Valeria; Fernández Sánchez, M.; Guadix, Dolores; et al.; Increased Expression of Aquaporin 9 in Trophoblast from Gestational Diabetic Patients; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 48; 8; 8-2016; 535-539
dc.identifier.issn
0018-5043
dc.identifier.uri
http://hdl.handle.net/11336/38903
dc.description.abstract
Gestational diabetes mellitus is the most frequent pathophysiological alteration in pregnancy, increasing the incidence of complications in both mother and fetus. The macrosomia that occurs in these fetuses may be related with some changes in nutrient transport mechanism in placenta. The presence of aquaporin 9, an aquaglyceroporin, has previously been demonstrated in placenta. We raised the question whether aquaporin 9 expression may be upregulated in placenta from gestational diabetes, thus providing a faster transport of glycerol and water through placenta. We studied 21 placentas (13 controls and 8 gestational diabetes) from cesarean delivery at term. The expression of aquaporin 9 was analyzed by quantitative PCR, immunoblot, and immunohistochemistry. The median values from quantitative PCR were compared by nonparametric tests for independent samples (Mann-Whitney U-test). We have found that trophoblast from gestational diabetes express higher amount of aquaporin 9, which was found statistically significant (p<0.05). The increase in aquaporin 9 expression was confirmed by immunoblot, and localization in the syncytiotrophoblast was checked by immunohistochemistry. The increase in aquaporin 9 expression in placenta from gestational diabetes may contribute to the higher transport rate in this pathology of pregnancy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Georg Thieme Verlag Kg
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aqp9
dc.subject
Aquaporins
dc.subject
Gestational Diabetes Mellitus
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Placenta
dc.title
Increased Expression of Aquaporin 9 in Trophoblast from Gestational Diabetic Patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-15T14:12:50Z
dc.journal.volume
48
dc.journal.number
8
dc.journal.pagination
535-539
dc.journal.pais
Alemania
dc.journal.ciudad
Stuttgart
dc.description.fil
Fil: Vilariño García, T.. Universidad de Sevilla; España
dc.description.fil
Fil: Pérez Pérez, A.. Universidad de Sevilla; España
dc.description.fil
Fil: Dietrich, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina
dc.description.fil
Fil: Fernández Sánchez, M.. Instituto Valenciano de Infertilidad; España
dc.description.fil
Fil: Guadix, Dolores. Universidad de Sevilla; España
dc.description.fil
Fil: Dueñas, J. L.. Universidad de Sevilla; España
dc.description.fil
Fil: Varone, Cecilia Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Damiano, Alicia Ermelinda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.description.fil
Fil: Sánchez Margalet, V.. Universidad de Sevilla; España
dc.journal.title
Hormone and Metabolic Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1055/s-0042-105152
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-105152


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