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dc.contributor.author
Postma, Gabriela
dc.contributor.author
Minatel, Leonardo
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Olivares, Roberto Walter Israel
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Schapira, Andrea
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Valdez, Laura Batriz
dc.contributor.author
Dallorso, Maria Elena
dc.date.available
2018-03-14T22:22:02Z
dc.date.issued
2016-05
dc.identifier.citation
Postma, Gabriela; Minatel, Leonardo; Olivares, Roberto Walter Israel; Schapira, Andrea; Valdez, Laura Batriz; et al.; Superoxide Dismutase Activity, Hydrogen Peroxide Steady-State Concentration, and Bactericidal and Phagocytic Activities Against Moraxella bovis, in Neutrophils Isolated from Copper-Deficient Bovines; Humana Press; Biological Trace Element Research; 171; 1; 5-2016; 94-100
dc.identifier.issn
0163-4984
dc.identifier.uri
http://hdl.handle.net/11336/38857
dc.description.abstract
Copper (Cu) deficiency increases occurrence of certain infectious diseases in animals, including infectious keratoconjunctivitis in bovines, a bacterial ocular inflammation caused by Moraxella bovis. Neutrophil leukocytes constitute the first phagocytic cells to arrive at infection sites for bacterial neutralization. The objective of this work was to evaluate whether the functionality of neutrophils against M. bovis is impaired in experimentally induced Cu deficiency in bovines using high molybdenum and sulfur levels in the diet. The Cu tissue values and the periocular achromotrichia observed in +Mo animals showed that the clinic phase of Cu deficiency was reached in this group. Instead, +Cu animals have not evidenced clinical signs or biochemical parameters of hypocuprosis. On the basis of our observations, we concluded that Cu deficiency has no effect on phagocytic and bactericidal activities of neutrophils against M. bovis. However, superoxide dismutase activity and peroxide hydrogen generation were significantly different between groups. Therefore, additional research to explain these results is merited to fully characterize the consequences of Cu status on the risk for infections under field conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Humana Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Calves
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Copper
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Innate Immunity
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Phagocytic Cells
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Respiratory Burst
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Trace Elements
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Superoxide Dismutase Activity, Hydrogen Peroxide Steady-State Concentration, and Bactericidal and Phagocytic Activities Against Moraxella bovis, in Neutrophils Isolated from Copper-Deficient Bovines
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-13T18:15:22Z
dc.journal.volume
171
dc.journal.number
1
dc.journal.pagination
94-100
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Postma, Gabriela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Minatel, Leonardo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Olivares, Roberto Walter Israel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Schapira, Andrea. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Valdez, Laura Batriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Dallorso, Maria Elena. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.journal.title
Biological Trace Element Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s12011-015-0505-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12011-015-0505-2
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